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Cholesterol Carbonate

中文名称
——
中文别名
——
英文名称
Cholesterol Carbonate
英文别名
[(8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] hydrogen carbonate
Cholesterol Carbonate化学式
CAS
——
化学式
C28H46O3
mdl
——
分子量
430.671
InChiKey
HSZZZVBVEHMHKY-UBTBPNKJSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    9.2
  • 重原子数:
    31
  • 可旋转键数:
    7
  • 环数:
    4.0
  • sp3杂化的碳原子比例:
    0.89
  • 拓扑面积:
    46.5
  • 氢给体数:
    1
  • 氢受体数:
    3

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
    胆固醇甲酰氯 Cholesteryl chloroformate 7144-08-3 C28H45ClO2 449.117

反应信息

  • 作为产物:
    描述:
    N,N-二甲基乙醇胺胆固醇甲酰氯碳酸氢钠 作用下, 以 二氯甲烷 为溶剂, 以85%的产率得到Cholesterol Carbonate
    参考文献:
    名称:
    Sustainded-release composition including amorphous polymer
    摘要:
    提供了一种用于缓慢释放药物物质的缓慢释放组合物。该组合物包括一种高度非晶态的生物相容性聚合物和一种与一种两性物质形成疏水离子复合物的药物物质。还提供了一种压缩反溶剂法制造该组合物的方法,包括该组合物的各种产品形式以及该组合物的各种用途。
    公开号:
    US20020132007A1
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文献信息

  • [EN] RELEASABLE CATIONIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEMS<br/>[FR] LIPIDES CATIONIQUES LIBÉRABLES POUR SYSTÈMES D'ADMINISTRATION D'ACIDES NUCLÉIQUES
    申请人:ENZON PHARMACEUTICALS INC
    公开号:WO2010057155A1
    公开(公告)日:2010-05-20
    The present invention is directed to releasable cationic lipids and nanoparticle compositions for the delivery of nucleic acids and methods of modulating an expression of a target gene using the same. In particular, the invention relates to cationic lipids including an acid labile linker, and nanoparticle compositions containing the same.
    本发明涉及可释放的阳离子脂质和纳米颗粒组合物,用于传递核酸并利用其调节靶基因的表达的方法。具体而言,本发明涉及包含酸敏感连接剂的阳离子脂质和含有该连接剂的纳米颗粒组合物。
  • BRANCHED CATIONIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEM
    申请人:Zhao Hong
    公开号:US20110305769A1
    公开(公告)日:2011-12-15
    The present invention is directed to cationic lipid for the delivery of oligonucleotides and methods of modulating an expression of a targeted gene using the nanoparticle compositions. In particular, the invention relates to cholesterol and its derivatives having multiple positively charged moieties via branching spacers, and nanoparticle compositions of oligonucleotides encapsulated in a mixture of a cationic lipid, a fusogenic lipid and a PEG lipid.
    本发明涉及用于递送寡核苷酸的阳离子脂质以及利用纳米粒子组合物调节靶向基因表达的方法。具体而言,本发明涉及通过分支间隔物具有多个带正电性的衍生物的胆固醇及其衍生物,以及封装在阳离子脂质、融合脂质和PEG脂质混合物中的寡核苷酸纳米粒子组合物。
  • Biocompatible cationic detergents and uses therefor
    申请人:University Technology Corporation
    公开号:US20020032166A1
    公开(公告)日:2002-03-14
    Provided is a method for preparing a true, homogeneous solution of a pharmaceutical substance dissolved in an organic solvent in which the pharmaceutical substance is not normally soluble. Solubilization is obtained by forming a hydrophobic ion pair complex involving the pharmaceutical substance and an amphiphilic material. The resulting organic solution may be further processed to prepare pharmaceutical powders. A biodegradable polymer may be co-dissolved with the pharmaceutical substance and the amphiphilic material and may be incorporated into a pharmaceutical powder. A preferred method for preparing pharmaceutical powders is to subject the organic solution to gas antisolvent precipitation using a supercritical gas antisolvent such as carbon dioxide. Also provided is a method for making hollow particles having a fiber-like shape which would provide enhanced retention time in the stomach if ingested by a human or animal host. Further provided are novel biocompatible cationic surfactants and uses therefor, including the delivery, in vitro and in vivo, of nucleic acids into cells to transform the cells.
    提供了一种制备药物物质在有机溶剂中真正均质溶解的方法,其中药物物质通常不溶于有机溶剂。通过形成涉及药物物质和两性分子材料的疏水离子对复合物来获得溶解度。所得到的有机溶液可以进一步处理以制备药物粉末。生物可降解聚合物可以与药物物质和两性分子材料共溶,并可以并入药物粉末中。制备药物粉末的首选方法是将有机溶液经过超临界气体反溶剂沉淀使用超临界气体反溶剂如二氧化碳。此外,提供了一种制备纤维状空心粒子的方法,如果被人类或动物宿主吞咽,将提供增强的胃滞留时间。还提供了新型生物相容阳离子表面活性剂及其用途,包括将核酸在体外和体内传递到细胞中以转化细胞。
  • NANOPARTICLE COMPOSITIONS FOR NUCLEIC ACIDS DELIVERY SYSTEM
    申请人:Zhao Hong
    公开号:US20110111044A1
    公开(公告)日:2011-05-12
    The present invention is directed to nanoparticle compositions for the delivery of oligonucleotides and methods of modulating an expression of a targeted gene using the nanoparticle compositions. In particular, the invention relates to oligonucleotides encapsulated in a mixture of a cationic lipid, a fusogenic lipid and a PEG lipid.
    本发明涉及纳米颗粒组合物,用于输送寡核苷酸并使用该纳米颗粒组合物调节靶向基因的表达的方法。特别地,该发明涉及封装在阳离子脂质、融合脂质和PEG脂质混合物中的寡核苷酸。
  • POLYOXYALKYLENE CHAIN-CONTAINING LIPID DERIVATIVE AND LIPID FILM STRUCTURE CONTAINING SUCH DERIVATIVE
    申请人:The University of Tokushima
    公开号:EP1854807A1
    公开(公告)日:2007-11-14
    A polyoxyalkylene chain-containing lipid derivative, which is represented by the following formula (1): wherein L, Y, W, X1, X2, X3, OA, Z, m1, m2, m3, n1, n2 and n3 are as defined in the specification.
    一种含有聚氧亚烷基链的脂质衍生物,由下式(1)表示: 其中 L、Y、W、X1、X2、X3、OA、Z、m1、m2、m3、n1、n2 和 n3 如说明书中所定义。
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