(2S)-1-amino-3-(propan-2-ylamino)propan-2-ol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2S)-1-amino-3-(propan-2-ylamino)propan-2-ol
• 化学式: C₆H₁₆N₂O
• 分子量: 132.2
• InChiKey: YNIKRGJRGCMOSG-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.3
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• METALLO-BETA-LACTAMASE INHIBITORS AND METHODS OF USE THEREOF
  申请人：PASTERNAK Alexander

  公开号：US20200375987A1

  公开（公告）日：2020-12-03

  The present invention relates to metallo-β-lactamase inhibitor compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein R A , R 1 , and Z are as defined herein. The present invention also relates to compositions which comprise a metallo-β-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.