Estra-1,3,5(10),16-tetraene-3 6-diol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Estra-1,3,5(10),16-tetraene-3 6-diol
• 英文别名: estra-1,3,5(10),16-tetraene-3,6-diol；Estra-1,3,5(10),16-tetraen-3,6-diol；(8S,9S,13R,14S)-13-methyl-6,7,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthrene-3,6-diol
• 化学式: C₁₈H₂₂O₂
• 分子量: 270.371
• InChiKey: PJJNDNQOKKSFGP-CKCLZSBESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吡啶 、 诺龙 以 甲苯 为溶剂， 以1.1 g (28%)的产率得到Estra-1,3,5(10),16-tetraene-3 6-diol
  参考文献：
  名称：

  Estrenes for inducing hypothalamic effects

  摘要：

  这项发明涉及雌甾烯类类固醇，它们结合到神经上皮受体上。该类固醇最好以含有一种或多种药用载体的药物组合物的形式进行给药。

  公开号：

  US05633392A1

文献信息

• Method of altering hypothalamic function by nasal administration of
  申请人：Pherin Corporation

  公开号：US05783571A1

  公开（公告）日：1998-07-21

  The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human semiochemical, e.g. an Estrene steroid, or a pharmaceutical composition containing an Estrene steroid, such that the ligand semiochemical binds to a specific neuroepithelial receptor. The steroid is preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers. Other embodiments of the invention include pharmaceutical compositions containing the steroids.

  本发明涉及一种改变个体下丘脑功能的方法。该方法包括鼻腔给予人类信号化合物，例如Estrene 类固醇，或含有Estrene类固醇的药物组合物，使配体信号化合物与特定的神经上皮受体结合。 该类固醇最好以含有一种或多种药用载体的药物组合物形式给予。发明的其他实施例包括含有这些类固醇的药物组合物。
• Steroids as neurochemical stimulators of the VNO to alleviate symptoms
  申请人：Pherin Corporation

  公开号：US06057439A1

  公开（公告）日：2000-05-02

  The invention relates to a method of alleviating the symptoms of PMS and anxiety. The method comprises nasally administering a steroid which is a human vomeropherin, such that the vomeropherin binds to a specific neuroepithelial receptor. The steroid or steroids is/are preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers.

  本发明涉及一种缓解经前综合症和焦虑症状的方法。该方法包括通过鼻腔给予一种类固醇激素，该激素是人类鼻骨分泌素，使该鼻骨分泌素与特定的神经上皮受体结合。该类固醇或类固醇通常以含有一种或多种药学上可接受载体的药物组合物的形式给予。
• Steroids as neurochemical initiators of change in human blood levels of
  申请人：Pherin Corporation

  公开号：US06066627A1

  公开（公告）日：2000-05-23

  The invention relates to a method of altering the blood levels of LH or FSH in an individual. The method comprises nasally administering a steroid which is a human vomeropherin, such that the vomeropherin binds to a specific neuroepithelial receptor. The steroid or steroids is/are preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers.

  本发明涉及一种改变个体LH或FSH血液水平的方法。该方法包括经鼻给药一种类固醇物质，该物质为人类鼻腔粘液蛋白，使其结合到特定的神经上皮受体上。该类固醇物质通常以含有一种或多种药学上可接受的载体的制药组合物的形式给予。
• Steroids as neurochemical stimulators of the VNO to treat paroxistic
  申请人：Pherin Pharmaceuticals, Inc.

  公开号：US06117860A1

  公开（公告）日：2000-09-12

  The invention relates to a method of alleviating the symptoms of PMS and anxiety. The method comprises nasally administering a steroid which is a human vomeropherin, such that the vomeropherin binds to a specific neuroepithelial receptor. The steroid or steroids is/are preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers.

  本发明涉及一种缓解经前综合症和焦虑症状的方法。该方法包括通过鼻腔给予一种类固醇激素即人类呕吐素，使呕吐素与特定神经上皮受体结合。该类固醇激素或多种类固醇激素优选以含有一种或多种药学上可接受的载体的药物组成物的形式给予。
• Steroids as neurochemical stimulators of the VNO to alleviate pain
  申请人：Pherin Pharmaceuticals, Inc.

  公开号：US06331534B1

  公开（公告）日：2001-12-18

  The invention relates to a method of alleviating pain. The method comprises nasally administering a steroid which is a human vomeropherin, such that the vomeropherin binds to a specific neuroepithelial receptor. The steroid or steroids is/are preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers.

  本发明涉及缓解疼痛的方法。该方法包括经鼻给予一种类固醇激素，该激素是人类鼻骨细胞素，以使鼻骨细胞素结合到特定的神经上皮受体上。该类固醇或类固醇通常以含有一种或多种药用载体的制剂形式给予。