5-bromo-N-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridine-3-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 5-bromo-N-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridine-3-carboxamide
• 化学式: C₁₆H₁₅BrN₂O
• 分子量: 331.21
• InChiKey: ZPXACHIUXSNLMG-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
  申请人：Tachdjian Catherine

  公开号：US20050084506A1

  公开（公告）日：2005-04-21

  The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers,—savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

  本发明涉及发现，某些非天然存在的非肽酰胺化合物和酰胺衍生物，如草酰胺、脲和丙烯酰胺，可用作风味或口味调节剂，例如风味或调味剂和风味或口味增强剂，更具体地说，是用于食品、饮料和其他可食用或口服药品或组合物的风味或口味调节剂，包括鲜味（味精的“鲜味”）或甜味调节剂，鲜味或甜味调味剂以及鲜味或甜味增强剂。
• NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI OR SWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF
  申请人：Tachdjian Catherine

  公开号：US20120201763A1

  公开（公告）日：2012-08-09

  The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, —savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

  本发明涉及到一些非自然生成、非肽酰胺化合物和酰胺衍生物的发现，例如草酰胺、脲和丙烯酰胺，这些化合物是有用的味道或口感调节剂，例如调味剂和增味剂，更特别地，是鲜味（单钠谷氨酸的“鲜味”）或甜味调节剂，- 鲜味或甜味调味剂和鲜味或甜味增强剂，用于食品、饮料和其他可食用或口服药物产品或组合物。
• Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
  申请人：SENOMYX, INC.

  公开号：US10060909B2

  公开（公告）日：2018-08-28

  The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers,—savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

  本发明涉及发现某些非天然存在的非肽酰胺化合物和酰胺衍生物，例如草酰胺、脲和丙烯酰胺，是有用的风味或口味调节剂，例如香料或调味剂以及风味或口味增强剂、尤其是咸味（谷氨酸钠的 "鲜味"）或甜味调节剂--咸味或甜味调味剂和咸味或甜味增味剂，可用于食品、饮料和其他可食用或口服的医药产品或组合物。
• CYCLOALKYLIDENE COMPOUNDS AS MODULATORS OF THE ESTROGEN RECEPTOR
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1667955A2

  公开（公告）日：2006-06-14
• [EN] CHEMICAL COMPOUNDS<br/>[FR] COMPOSES CHIMIQUES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2005012220A2

  公开（公告）日：2005-02-10

  The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation. Formula (I) including salts, solvates, and pharmacologically functional derivatives thereof wherein R1 is OH; each of R2 and R4 independently are selected from OH, alkyl, or halogen; each of p and q independently are selected from 0, 1, or 2; R3 is -(Y)z-R6; z is 0 or 1; Y is -C=C- or CR6=CR1-; X is -(CH2)n- where n is 0, 1, 2, or 3, -C(R9)2-, -O-,or -S-.