2,3-bis-(3,4,5-trimethoxybenzamido)-phenazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2,3-bis-(3,4,5-trimethoxybenzamido)-phenazine
• 英文别名: N-[3-[[hydroxy-(3,4,5-trimethoxyphenyl)methylidene]amino]phenazin-2-yl]-3,4,5-trimethoxybenzenecarboximidic acid
• 化学式: C₃₂H₃₀N₄O₈
• 分子量: 598.612
• InChiKey: WCFYEYNKFZVHAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  44
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  139
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  2,3-bis-(3,4,5-trimethoxybenzamido)-phenazine 、 双氧水 以41%的产率得到
  参考文献：
  名称：

  SLUKA J.; ZIKAN V.; DANEK J., CS. FARM., 36,(1987) N 1, 25-28

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3-二氨基吩嗪 、 3,4,5-三甲氧基苯甲酸 在 三氯氧磷 作用下， 反应 6.0h， 以48%的产率得到2,3-bis-(3,4,5-trimethoxybenzamido)-phenazine
  参考文献：
  名称：

  On the Synthesis of Pyrazino[2,3-b]phenazine and 1H-Imidazo[4,5-b]phenazine Derivatives

  摘要：

  Several pyrazino[2,3-D]phenazine derivatives were prepared by the reaction of 2,3-diaminophenazine with different 1,2-diketones. Nucleophilic substitution of 2,3-dibromomethyl-pyrazino[2,3-b]phenazine with propanol, morpholine, and potassium thiocyanate gave 2,3-bis(propoxymethyl)-pyrazino[2,3-b]phenazine 2,3-bis-(4-morpholinylmethyl)-pyrazino[2,3-b]phenazine, and 2,3-bis-(cyanosulfanylmethyl)-pyrazino[2,3-b]phenazine. 2-Aryl-1H-imidazo[4,5-b]phenazine derivatives were synthesized by a one-pot reaction of 1,3-diaminophenazine with different aromatic aldehydes or acids. Reaction of 2,3-diaminophenazine with acetic anhydride and formic acid afforded 1H-imidazo[4,5-b]phenazine and 2-methyl-1H-imidazo[4,5-b]phenazine. Chemical and spectroscopic evidences for the product structures of the new compounds are presented.

  DOI：

  10.1007/pl00010183

文献信息

• SLUKA J.; ZIKAN V.; DANEK J., CS. FARM., 36,(1987) N 1, 25-28
  作者：SLUKA J.、 ZIKAN V.、 DANEK J.

  DOI：——

  日期：——
• On the Synthesis of Pyrazino[2,3-b]phenazine and 1H-Imidazo[4,5-b]phenazine Derivatives
  作者：Atef M. Amer、Adel A. El-Bahnasawi、Mohamed R. H. Mahran、Mostafa Lapib

  DOI：10.1007/pl00010183

  日期：1999.10

  Several pyrazino[2,3-D]phenazine derivatives were prepared by the reaction of 2,3-diaminophenazine with different 1,2-diketones. Nucleophilic substitution of 2,3-dibromomethyl-pyrazino[2,3-b]phenazine with propanol, morpholine, and potassium thiocyanate gave 2,3-bis(propoxymethyl)-pyrazino[2,3-b]phenazine 2,3-bis-(4-morpholinylmethyl)-pyrazino[2,3-b]phenazine, and 2,3-bis-(cyanosulfanylmethyl)-pyrazino[2,3-b]phenazine. 2-Aryl-1H-imidazo[4,5-b]phenazine derivatives were synthesized by a one-pot reaction of 1,3-diaminophenazine with different aromatic aldehydes or acids. Reaction of 2,3-diaminophenazine with acetic anhydride and formic acid afforded 1H-imidazo[4,5-b]phenazine and 2-methyl-1H-imidazo[4,5-b]phenazine. Chemical and spectroscopic evidences for the product structures of the new compounds are presented.