evofolin B

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: evofolin B
• 英文别名: (-)-Evofolin B；(2S)-3-hydroxy-1,2-bis(4-hydroxy-3-methoxyphenyl)propan-1-one
• 化学式: C₁₇H₁₈O₆
• 分子量: 318.326
• InChiKey: QMYGRGKKZBRZKH-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  stroside A 在 β-glucosidase 作用下， 以 水 为溶剂， 反应 48.0h， 以0.2 mg的产率得到evofolin B
  参考文献：
  名称：

  Phenolic Derivatives from the Stems of Lagerstroemia indica and Their Biological Activity

  摘要：

  The purification of a MeOH extract from the stems of Lagerstroemia indica (Lythraceae) using repeated column chromatography afforded three new phenolic glycosides (1-3), and a new flavone derivative (4) along with fifteen known compounds (5-19). The structures of new compounds were determined through spectral analysis, including 1D, 2D-NMR and MS data. Compounds 1-19 were evaluated for their inhibitory activities on nitric oxide (NO) production in an activated murine microglial cell line and cytotoxic activities against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15).

  DOI：

  10.3987/com-15-13328

文献信息

• Phenolic Derivatives from the Stems of Lagerstroemia indica and Their Biological Activity
  作者：Kang Ro Lee、Kyeong Wan Woo、Lalita Subedi、Sun Yeou Kim、Sang Un Choi、Won Se Suh

  DOI：10.3987/com-15-13328

  日期：——

  The purification of a MeOH extract from the stems of Lagerstroemia indica (Lythraceae) using repeated column chromatography afforded three new phenolic glycosides (1-3), and a new flavone derivative (4) along with fifteen known compounds (5-19). The structures of new compounds were determined through spectral analysis, including 1D, 2D-NMR and MS data. Compounds 1-19 were evaluated for their inhibitory activities on nitric oxide (NO) production in an activated murine microglial cell line and cytotoxic activities against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15).