2-(sec-butylthio)benzo[d]oxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 2-(sec-butylthio)benzo[d]oxazole
• 英文别名: 2-Butan-2-ylsulfanyl-1,3-benzoxazole；2-butan-2-ylsulfanyl-1,3-benzoxazole
• 化学式: C₁₁H₁₃NOS
• 分子量: 207.296
• InChiKey: CLSVVYRCYADWAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  51.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基苯酚 在 potassium carbonate 作用下， 以 水 为溶剂， 生成 2-(sec-butylthio)benzo[d]oxazole
  参考文献：
  名称：

  水性介质中2-烷基硫代苯并三唑的三组分合成

  摘要：

  描述了一种用于合成2-烷基硫代苯并唑的高效三组分方案。四甲基秋兰姆二硫化物（TMTD）与邻氨基硫酚进行环化，生成中间体2-巯基苯并噻唑，并与卤代烷烃连续进行C-S偶联，从而在一个一锅过程中平稳地获得了一系列2-烷基取代的硫代苯并噻唑。该方法也可用于制备2-烷基取代的硫代苯并恶唑和2-烷基取代的硫代苯并咪唑。廉价且容易获得的原料，无金属催化剂，广泛的底物范围以及以水为溶剂是该协议的特点。

  DOI：

  10.1055/s-0039-1690854

文献信息

• Three‐Component Synthesis of 2‐Substituted Thiobenzoazoles Using Tetramethyl Thiuram Monosulfide (TMTM) as Thiocarbonyl Surrogate
  作者：Xi Wang、Chun‐Yan Wu、Yue‐Sheng Li、Zhi‐Bing Dong

  DOI：10.1002/ejoc.202001214

  日期：2020.11.22

  A metal‐free synthesis of 2‐benzyl/allyl‐substituted thiobenzoazoles was developed starting from tetramethyl thiuram monosulfide (TMTM) which served as thiocarbonyl surrogate. By using 2‐aminophenols (or 2‐aminothiophenols, or 1,2‐phenylenediamines) and TMTM as starting materials, 2‐mercaptobenzoazoles could be synthesized efficiently, and the subsequent C–S bond formation with allyl/benzyl halides

  从用作硫代羰基替代物的四甲基秋兰姆单硫化物（TMTM）出发，开发了2-苄基/烯丙基取代的硫代苯并恶唑的无金属合成方法。通过使用2-氨基苯酚（或2-氨基硫酚或1,2-苯二胺）和TMTM作为起始原料，可以高效合成2-巯基苯并恶唑，随后与烯丙基/苄基卤化物的CS键形成最终产物（ 2-烯丙基/苄基取代的硫代苯并唑），具有良好或优异的收率。
• Inhibiting germination of clostridium perfringens spores to reduce necrotic enteritis
  申请人：The Board of Regents of the Nevada System of Higher Education on Behalf of the University of Nevada

  公开号：US10945996B2

  公开（公告）日：2021-03-16

  Provided herein are materials and methods useful for reducing, preventing, and/or inhibiting germination of C. perfringens spores, including methods for inhibiting C. perfringens germination to reduce necrotizing enteritis (NE, also referred to as necrotic enteritis) in animals. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本文提供了用于减少、预防和/或抑制C. perfringens孢子萌发的材料和方法，包括抑制C. perfringens萌发以减少动物坏死性肠炎（NE，也称为坏死性肠炎）的方法。本摘要旨在作为特定技术领域的扫描工具，供检索之用，并非对本发明的限制。
• Inhibiting Germination of Clostridium Perfringens Spores to Reduce Necrotic Enteritis
  申请人：Abel-Santos Ernesto

  公开号：US20180000793A1

  公开（公告）日：2018-01-04

  Provided herein are materials and methods useful for reducing, preventing, and/or inhibiting germination of C. perfringens spores, including methods for inhibiting C. perfringens germination to reduce necrotizing enteritis (NE, also referred to as necrotic enteritis) in animals. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• [EN] INHIBITING GERMINATION OF CLOSTRIDIUM PERFRINGENS SPORES TO REDUCE NECROTIC ENTERITIS<br/>[FR] INHIBITION DE LA GERMINATION DES SPORES DE CLOSTRIDIUM PERFRINGENS POUR RÉDUIRE L'ENTÉRITE NÉCROTIQUE
  申请人：ABEL-SANTOS ERNESTO

  公开号：WO2016127102A2

  公开（公告）日：2016-08-11

  Provided herein are materials and methods useful for reducing, preventing, and/or inhibiting germination of C. perfringens spores, including methods for inhibiting C.perfringens germination to reduce necrotizing enteritis (NE, also referred to as necrotic enteritis) in animals. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• Three-Component Synthesis of 2-Alkylthiobenzoazoles in Aqueous Media
  作者：Zhi-Bing Dong、Jin-Quan Chen、Jia Guo

  DOI：10.1055/s-0039-1690854

  日期：2020.7

  A highly efficient three-component protocol for the synthesis of the 2-alkylthiobenzoazoles is described. Tetramethylthiuram disulfide (TMTD) cyclized with o-aminothiophenols, generating the intermediate 2-mercaptobenzothiazoles, and the successive C–S coupling with halogenated alkanes afforded a series of 2-alkyl-substituted thiobenzothiazoles smoothly in a one-pot process. This procedure could also

  描述了一种用于合成2-烷基硫代苯并唑的高效三组分方案。四甲基秋兰姆二硫化物（TMTD）与邻氨基硫酚进行环化，生成中间体2-巯基苯并噻唑，并与卤代烷烃连续进行C-S偶联，从而在一个一锅过程中平稳地获得了一系列2-烷基取代的硫代苯并噻唑。该方法也可用于制备2-烷基取代的硫代苯并恶唑和2-烷基取代的硫代苯并咪唑。廉价且容易获得的原料，无金属催化剂，广泛的底物范围以及以水为溶剂是该协议的特点。