1,4-bis(4-methylpiperazino)benzene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,4-bis(4-methylpiperazino)benzene
• 英文别名: 1-Methyl-4-[4-(4-methylpiperazin-1-yl)phenyl]piperazine
• 化学式: C₁₆H₂₆N₄
• 分子量: 274.409
• InChiKey: FSXDNLOEXIDXAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  13
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-哌嗪甲酸乙酯 、 1,4-二氯苯 在 镍 苯乙烯 、 2,2'-联吡啶 、 sodium tert-pentoxide 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 1,4-bis(4-methylpiperazino)benzene
  参考文献：
  名称：

  Nickel-catalysed couplings of aryl chlorides with secondary amines and piperazines

  摘要：

  The reaction of aryl chlorides with secondary amines or piperazines in the presence of an in situ generated liganded nickel catalyst gives arylamines in good yields. Our process provides a mild, convenient and cheap method of arylamination starting from readily available substrates. (C) 1999;Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00788-7

文献信息

• Manipulation of the reduction potentials of Wurster's blue derivatives via steric and conformational effects
  作者：Anthony J. Pearson、Ann M. Gelormini

  DOI：10.1016/s0040-4039(97)01091-5

  日期：1997.7

  and 2-alkyl tetra-alkyl-p-phenylenediamines have been prepared. The amine/amine·+ first redox couple has been determined for each member of the series and is influenced by remote steric, electronic, and conformational effects.

  使用[η 6 -cyclopentadienyliron] +介导的小号Ñ氩化学，一系列对称和2-烷基四-烷基-的p苯二胺已经制备。已确定该系列的每个成员的胺/胺·+第一氧化还原对，并受远程空间，电子和构象效应的影响。
• Preparation of Functionalized <i>p</i><b>-Phenylenediamine Derivatives Using Arene−Iron Chemistry</b>
  作者：Anthony J. Pearson、Ann M. Gelormini、Marye Anne Fox、Diana Watkins

  DOI：10.1021/jo951677l

  日期：1996.1.1

  Selective displacement of chloride from cyclopentadienyl(1,4-dichlorobenzene)iron(1+) by a series of cyclic secondary amine nucleophiles is described. This selectivity, in combination with further manipulation of the complexes, allows access to a series of unsymmetrical and/or functionalized tetraalkyl-p-phenylenediamine complexes. A series of demetalated phenylenediamines were shown by CV to have redox potentials distributed over a range of 320 mV, as a consequence of remote functionality. Preliminary fluorescence studies on a series of electron acceptor-substituted phenylenediamines indicated quenching of the phenylenediamine fluorescence, attributable to rapid electron transfer.