rivastigmine pamoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: rivastigmine pamoate
• 英文别名: 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid;[3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate
• 化学式: C₁₄H₂₂N₂O₂*C₂₃H₁₆O₆
• 分子量: 638.717
• InChiKey: DOIVMBUYHORPGG-WUSPCOQVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.15
• 重原子数：
  47
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  148
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  利凡斯的明 生成 rivastigmine pamoate
  参考文献：
  名称：

  LONG-LASTING FORMULATION CONTAINING RIVASTIGMINE, AND METHOD FOR PREPARING SAME

  摘要：

  The present invention relates to a sustained release microsphere for long-lasting injectable formulations comprising one or more active ingredients selected from the group consisting of rivastigmine and pharmaceutically acceptable poorly soluble salts thereof and a biodegradable polymer, and a long-lasting injectable formulation for preventing or treating Alzheimer's disease comprising the same and a method for preparing the microsphere, and it can reduce side effects of the patient's gastrointestinal tract, which are frequently seen in conventional oral administration agents, and increase the adaptability of taking medicine, thereby maximizing the therapeutic effect, by providing a long-lasting injectable formulation comprising a rivastigmine sustained release microsphere, which has a high content while effectively controlling the initial burst drug release.

  公开号：

  US20220257518A1

文献信息

• [EN] DONEPEZIL PAMOATE, PREPARATION METHODE AND ITS USE<br/>[FR] PAMOATE DE DONÉPEZILE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
  申请人：GU ZIQIANG

  公开号：WO2013079007A1

  公开（公告）日：2013-06-06

  The composition containing a pamoate salt of donepezil, the method of preparation and the use thereof are disclosed.

  揭示了含有多奈哌齐的帕莫酸盐的组合物、其制备方法和用途。
• DONEPEZIL PAMOATE, METHOD OF PREPARATION AND USE THEREOF
  申请人：Gu Ziqiang

  公开号：US20140315952A1

  公开（公告）日：2014-10-23

  The composition containing a pamoate salt of donepezil, the method of preparation and the use thereof are disclosed.

  揭示了含有多奈哌齐的帕莫酸盐的组合物，其制备方法和用途。
• Memantine pamoate, method of preparation and use thereof
  申请人：Gu Zi-Qiang

  公开号：US10272031B2

  公开（公告）日：2019-04-30

  The composition containing a pamoate salt of donepezil, the method of preparation and the use thereof are disclosed.

  本发明公开了含有多奈哌齐的帕莫酸酯盐的组合物及其制备方法和用途。
• Pamoate salts and methods of use
  申请人：Gu Zi-Qiang

  公开号：US10478395B2

  公开（公告）日：2019-11-19

  The composition containing a pamoate salt of donepezil, the method of preparation and the use thereof are disclosed.

  本发明公开了含有多奈哌齐的帕莫酸酯盐的组合物及其制备方法和用途。
• Donezil pamoate, method of preparation and use thereof
  申请人：Gu Zi-Qiang

  公开号：US10952958B2

  公开（公告）日：2021-03-23

  The composition containing a pamoate salt of donepezil, the method of preparation and the use thereof are disclosed.

  本发明公开了含有多奈哌齐的帕莫酸酯盐的组合物及其制备方法和用途。