2,2'-terephthaloyldioxy-di-benzoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: 2,2'-terephthaloyldioxy-di-benzoic acid
• 英文别名: Terephthalsaeure-bis-(2-carboxy-phenylester)；2,2'-Terephthaloyldioxy-di-benzoesaeure；Terephthalyldisalicylsaeure；2-[4-(2-Carboxyphenoxy)carbonylbenzoyl]oxybenzoic acid
• 化学式: C₂₂H₁₄O₈
• 分子量: 406.348
• InChiKey: UMAPIIGKAZDJPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2,2'-terephthaloyldioxy-di-benzoic acid 、 乙酸酐 以100%的产率得到bis(2-acetyloxycarbonylphenyl) benzene-1,4-dicarboxylate
  参考文献：
  名称：

  Effect of Linker Structure on Salicylic Acid-Derived Poly(anhydride−esters)

  摘要：

  A series of salicylic acid-derived poly(anhydride -esters) were synthesized by melt polymerization methods, in which the structures of the molecule ("linker") linking together the two salicylic acids were varied. To determine the relationship between the linker and the physical properties of the corresponding poly(anhydride-ester), several linkers were evaluated including linear aliphatic, aromatic, and aliphatic branched structures. For the linear aliphatic linkers, higher molecular weights were obtained with longer linear alkyl chains. The most sterically hindered linkers yielded lower molecular weight polymers. The thermal decomposition temperature increased with the alkyl chain length, but the glass transition temperature decreased, due to the enhanced flexibility of the polymer. The highest glass transition temperatures were obtained by using aromatic linkers as a result of inereased pi-pi interactions. Water contact angles determined the relative hydrophobicity of the polymers, which correlated to hydrolytic degradation rates; i.e., the highest contact angle values yielded the slowest degrading polymers.

  DOI：

  10.1021/ma048051u
• 作为产物：
  描述：

  对苯二甲酰氯 、 水杨酸 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 以92%的产率得到2,2'-terephthaloyldioxy-di-benzoic acid
  参考文献：
  名称：

  Effect of Linker Structure on Salicylic Acid-Derived Poly(anhydride−esters)

  摘要：

  A series of salicylic acid-derived poly(anhydride -esters) were synthesized by melt polymerization methods, in which the structures of the molecule ("linker") linking together the two salicylic acids were varied. To determine the relationship between the linker and the physical properties of the corresponding poly(anhydride-ester), several linkers were evaluated including linear aliphatic, aromatic, and aliphatic branched structures. For the linear aliphatic linkers, higher molecular weights were obtained with longer linear alkyl chains. The most sterically hindered linkers yielded lower molecular weight polymers. The thermal decomposition temperature increased with the alkyl chain length, but the glass transition temperature decreased, due to the enhanced flexibility of the polymer. The highest glass transition temperatures were obtained by using aromatic linkers as a result of inereased pi-pi interactions. Water contact angles determined the relative hydrophobicity of the polymers, which correlated to hydrolytic degradation rates; i.e., the highest contact angle values yielded the slowest degrading polymers.

  DOI：

  10.1021/ma048051u

文献信息

• Stretched film structure of the poly-1,3-phenylene terephthalate type
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0052927A2

  公开（公告）日：1982-06-02

  A monoaxially or biaxially stretched film structure, or a heat-set structure thereof, of an unstretched film of an aromatic polyester having an intrinsic viscosity, determined in p-chlorophenol at 50°C, of 0.4 to 2.0 and composed of [A] polybasic carboxylic acid component units consisting of terephthalic acid units (a1) and units (a2) of a polybasic carboxylic acid otherthan terephthalic acid, the proportion of the units (a2) being up to 25 mole% based on the units (a,) and units (a2) combined, and [B] polyol component units consisting of resorcinol units (b1) and units (b2) of a polyol other than resorcinol, the proportion of the units (b2) being up to 25 mole% based on the units (b1) and (b2) combined.

  一种单轴或双轴拉伸薄膜结构，或其热固结构，由芳香族聚酯的未拉伸薄膜组成，其固有粘度（在对氯苯酚中于 50℃测定）为 0.4 至 2.A] 由对苯二甲酸单元（a1）和对苯二甲酸以外的多基性羧酸单元（a2）组成的多基性羧酸组分单元，单元（a2）的比例为单元（a. ）和单元（a2）总和的 25 摩尔%、)和单元(a2)的总和，单元(a2)的比例不超过 25 摩尔%，以及 [B] 由间苯二酚单元(b1)和间苯二酚以外的多元醇单元(b2)组成的多元醇组分单 元，单元(b2)的比例不超过 25 摩尔%，单元(b1)和单元(b2)的总和。
• DE400970
  申请人：——

  公开号：——

  公开（公告）日：——
• Di-Aspirin Derivatives
  申请人：Perry Christopher John

  公开号：US20130035317A1

  公开（公告）日：2013-02-07

  The invention relates to the use of di-aspirin (bis(2-carboxyphenyl)succinate) and its derivatives in the treatment of colon and colorectal cancer. It also relates to novel derivatives of di-aspirin and to a method of synthesis of the di-aspirin and its derivatives.
• US9351980B2
  申请人：——

  公开号：US9351980B2

  公开（公告）日：2016-05-31
• [EN] DI-ASPIRIN DERIVATIVES<br/>[FR] DÉRIVÉS DE DIASPIRINE
  申请人：UNIV WOLVERHAMPTON

  公开号：WO2011098839A2

  公开（公告）日：2011-08-18

  The invention relates to the use of di-aspirin (bis(2-carboxyphenyl)succinate) and its derivatives in the treatment of colon and colorectal cancer. It also relates to novel derivatives of di-aspirin and to a method of synthesis of the di-aspirin and its derivatives.