Ethylphenyldichlorosilane is a colorless liquid with a pungent odor. It is decomposed by water to hydrochloric acid with evolution of heat. It is corrosive to metals and tissue.
颜色/状态：
Colorless liquid
气味：
SHARP ODOR LIKE HYDROCHLORIC ACID
分解：
The silanes decomp at elevated temp to liberate hydrogen and deposit a high purity silicon, which leads to some of the principal uses of silanes. /Silanes/
汽化热：
103 BTU/LB = 57 CAL/G = 2.4X10+5 JOULES/KG
保留指数：
1240
稳定性/保质期：
1. 具有腐蚀性且低毒。遇水会释放出有毒的氯化氢气体，在火灾中则会产生有毒的氯化氢和酚气体。
计算性质
辛醇/水分配系数(LogP)：
3.05
重原子数：
11
可旋转键数：
2
环数：
1.0
sp3杂化的碳原子比例：
0.25
拓扑面积：
0
氢给体数：
0
氢受体数：
0
ADMET
代谢
氯硅烷在与组织液接触时，会迅速水解释放氯化氢。
... Chlorosilanes will be rapidly hydrolyzed upon contact with tissue fluids to release hydrochloric acid. /Chlorosilanes/
来源:Hazardous Substances Data Bank (HSDB)
毒理性
副作用
Dermatotoxin - 皮肤烧伤。
Dermatotoxin - Skin burns.
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Silane, Chlorosilane, and Related Compounds/
Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal (refer to ingestion protocol in Section Three ... . Cover skin burns with sterile dressings after decontamination ... . /Silane, Chlorosilane, and Related Compounds/
Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Early intubation at the first sign of upper airway obstruction may be necessary. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Silane, Chlorosilane, and related compounds/
/SIGNS AND SYMPTOMS/ Acute inhalation exposure may result in sneezing, choking, laryngitis, dyspnea (shortness of breath), respiratory tract irritation, and chest pain. Higher exposure can cause pulmonary edema, a medical emergency that can be delayed for several hours. This can cause death. Bleeding of nose and gums, ulceration of the nasal and oral mucosa, pulmonary edema, chronic bronchitis, and pneumonia may also occur. If the eyes have come in contact with dimethyldichlorosilane, irritation, pain, swelling, corneal erosion, and blindness may result. Dermatitis (red, inflamed skin), severe burns, pain, and shock generally follow dermal exposure. Inhalation irritates mucous membranes. Severe gastrointestinal damage may occur. Vapors cause severe eye and lung injury. Upon short contact, second and third degree burns may occur. Signs and symptoms of acute ingestion of dimethyldichlorosilane may be severe and include increased salivation, intense thirst, difficulty swallowing, chills, pain, and shock. Oral, esophageal, and stomach burns are common. /Dimethyldichlorosilane/
The catalytic asymmetric creation of silanes with silicon stereocenters is a long‐sought but underdeveloped topic, and only a handful of examples have been reported. Moreover, the construction of chiral silanes containing (more than) two stereocenters is a more arduous task and remains unexploited. We herein report an unprecedented copper‐catalyzed desymmetrizing protoboration of divinyl‐substituted
Optically active silanes were synthesized by a novel asymmetric synthesis which involved the diastereoselective ring-opening reaction of 1,3-dioxa-2-silacycloheptanes bearing a C2 chiral auxiliary with Grignard reagents, followed by a lithium aluminum hydride (LiAlH4) reduction. (R)-Ethylmethylphenylsilane and (R)-methylphenylpropylsilane were derived in 93%ee and 98%ee, respectively. The preparation
Nickel‐catalyzed cross‐coupling reactions of chlorosilanes with organoaluminum reagents were developed. An electron‐rich Ni(0)/PCy3 complex was found to be an effective catalyst for the desired transformation. The reaction of dichlorosilanes 1 proceeded to give the corresponding monosubstituted products 2. Trichlorosilanes 4 underwent selective double substitution to furnish the corresponding monochlorosilanes
Living Cyclopolymerization of 1,6-Heptadiyne Derivatives Using Well-Defined Alkylidene Complexes: Polymerization Mechanism, Polymer Structure, and Polymer Properties
作者：Harold H. Fox、Michael O. Wolf、Richard O'Dell、Beatrice L. Lin、Richard R. Schrock、Mark S. Wrighton
DOI：10.1021/ja00086a016
日期：1994.4
Mo(NAr)(CHCMe[sub2]Ph)(OR[sub F6])[sub2] (1a; Ar = 2,6-i-Pr[sub2]C[sub 6]H[sub 3], OR[sub F6] = OCMe(CF[sub 3])[sub2]) as the initiator in 1,2-dimethoxyethane (DME). The polymers show a high degree of conjugation ([lambda][sub max] > 500 nm) and have narrow molecular weight distributions. Poly(2a) is soluble in most organic solvents (THF, C[sub 6]H[sub 6], toluene, CH[sub2]Cl[sub2], CHCl[sub 3], DME
Si–C bond cleavage by hydride complexes of rhodium and iridium: comparison of Si–C(sp2) and Si–C(sp3) activation
作者：Hajime Kameo、Sho Ishii、Hiroshi Nakazawa
DOI：10.1039/c3dt32896a
日期：——
Single Si–CR (R = Ph, Me, Et) bond activation in o-(Ph2P)C6H4}2Si(Me)(R) induced by Rh(H)(CO)(PPh3)3 was developed. The efficiency of Si–CR bond breaking reactions increased at 60 °C in the order Si–CEt < Si–CMe < Si–CPh and strongly depended on the reaction temperature. Elevating the reaction temperature promoted Si–CMe over Si–CPh bond activation, demonstrating that Si–CMe cleavage is entropically
由Rh（H）（CO）（PPh 3）诱导的 o-（Ph 2 P）C 6 H 4 } 2 Si（Me）（R）中的单个Si– CR（R = Ph，Me，Et）键活化）3已开发。Si-C R键断裂反应的效率在60°C时以Si-C Et
