2-amino-6-methacrylamidopyridine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-amino-6-methacrylamidopyridine
• 英文别名: N-(6-aminopyridin-2-yl)-2-methylprop-2-enamide
• 化学式: C₉H₁₁N₃O
• 分子量: 177.206
• InChiKey: ZYONWWHWCIYROL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  68
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,6-二氨基吡啶 、 甲基丙烯酸酐 在 2,6-二叔丁基-4-甲基苯酚 、 三乙胺 作用下， 以 氯仿 为溶剂， 反应 2.0h， 以50%的产率得到2-amino-6-methacrylamidopyridine
  参考文献：
  名称：

  Control of A Multisubunit DNA Motor by a Thermoresponsive Polymer Switch

  摘要：

  The conjugation of thermoresponsive polymers to multisubunit, multifunctional hybrid type 1 DNA restriction-modification (R-M) enzymes enables temperature-controlled "switching" of DNA methylation by the conjugate. Polymers attached to the enzyme at a subunit distal to the methylation subunit allow retention of DNA recognition and ATPase activity while controlling methylation of plasmid DNA. This regulation of enzyme activity arises from the coil-globule phase transitions of the polymer as shown in light scattering and gel retardation assays.

  DOI：

  10.1021/ja045275j

文献信息

• Functional monomers for molecular recognition and catalysis
  申请人：Sellergren Borje

  公开号：US20070106041A1

  公开（公告）日：2007-05-10

  The present invention refers to new classes of polymerisable monomers, to molecularly imprinted polymers obtainable by polymerisation of at least one of the monomers and a crosslinking monomer in the presence of a template molecule. The obtained polymers may be used for separation of enantiomers, diastereomers of the template molecule, and also for separation of the template molecule or template molecule analogues from structurally related compounds.

  本发明涉及一种新型可聚合单体，以及通过在模板分子存在下聚合至少一种单体和交联单体而获得的分子印迹聚合物。所获得的聚合物可用于分离模板分子的对映体、对映异构体，并且还可用于分离模板分子或类似物与结构相关化合物。
• US7208557B2
  申请人：——

  公开号：US7208557B2

  公开（公告）日：2007-04-24
• US7332553B2
  申请人：——

  公开号：US7332553B2

  公开（公告）日：2008-02-19
• Control of A Multisubunit DNA Motor by a Thermoresponsive Polymer Switch
  作者：Sivanand S. Pennadam、Matthieu D. Lavigne、Christina F. Dutta、Keith Firman、Darren Mernagh、Dariusz C. Górecki、Cameron Alexander

  DOI：10.1021/ja045275j

  日期：2004.10.1

  The conjugation of thermoresponsive polymers to multisubunit, multifunctional hybrid type 1 DNA restriction-modification (R-M) enzymes enables temperature-controlled "switching" of DNA methylation by the conjugate. Polymers attached to the enzyme at a subunit distal to the methylation subunit allow retention of DNA recognition and ATPase activity while controlling methylation of plasmid DNA. This regulation of enzyme activity arises from the coil-globule phase transitions of the polymer as shown in light scattering and gel retardation assays.