4',5'-diaminofluorescein

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 4',5'-diaminofluorescein
• 英文别名: 4',5'-diamino-3',6'-dihydroxy-spiro[phthalan-1,9'-xanthen]-3-one；4',5'-Diamino-3',6'-dihydroxy-spiro[phthalan-1,9'-xanthen]-3-on；4',5'-Diamino-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
• 化学式: C₂₀H₁₄N₂O₅
• 分子量: 362.342
• InChiKey: YIEXFFBMZZVZGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  27
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  128
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 4',5'-diaminofluorescein 在 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以60%的产率得到4',5'-bis(dimethylamino)fluorescein
  参考文献：
  名称：

  플루오레세인 유도체, 이의 제조방법 및 이를 이용한 pH 센서

  摘要：

  这项发明提供了一种氟螺酮衍生物、其制备方法以及pH传感器的使用，其中所述的氟螺酮衍生物由化学式1或化学式2表示; [化学式1]，[化学式2]。

  公开号：

  KR101922351B1
• 作为产物：
  描述：

  4 ,5-二硝基荧光素 在 palladium on activated charcoal 、 氢气 作用下， 反应 4.0h， 以66%的产率得到4',5'-diaminofluorescein
  参考文献：
  名称：

  플루오레세인 유도체, 이의 제조방법 및 이를 이용한 pH 센서

  摘要：

  这项发明提供了一种氟螺酮衍生物、其制备方法以及pH传感器的使用，其中所述的氟螺酮衍生物由化学式1或化学式2表示; [化学式1]，[化学式2]。

  公开号：

  KR101922351B1

文献信息

• Formation and use of embedded solutions in nanoscale materials
  申请人：The Regents of the University of California

  公开号：US11531025B2

  公开（公告）日：2022-12-20

  Provided herein are methods and materials that allow targeting and imaging of interactions between probes and targets. In some embodiments, the probes include nanoscale materials with embedded solutions that can be used to measure physical enhancement by materials under X-ray irradiation. In some embodiments, the methods of the present invention include delivering a probe material to a target that can have a delivered donor material. In some embodiments, methods of the present invention include irradiating the target and determining an optical change in the probe characteristic of a physical enhancement.

  本文提供的方法和材料可对探针和目标之间的相互作用进行定位和成像。在一些实施例中，探针包括具有嵌入溶液的纳米级材料，可用于测量材料在 X 射线照射下的物理增强。在一些实施例中，本发明的方法包括将探针材料输送到靶标，该靶标可以有输送的供体材料。在一些实施例中，本发明的方法包括照射目标并确定探针中物理增强特征的光学变化。
• BACTERIA TARGETING NANOPARTICLES AND RELATED METHODS OF USE
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20150306238A1

  公开（公告）日：2015-10-29

  The present invention relates to bacteria-targeting nanoparticles and related methods of use. In particular, the present invention relates to dendrimer nanoparticles conjugated with Vancomycin and/or Polymixin (e.g., Polymixin B, Polymixin E). In certain embodiments, such dendrimer nanoparticles are used to sequester and/or identify bacteria (e.g., Gram-positive bacteria and/or Gram-negative bacteria), screen liquid samples (e.g., water samples, food samples, pharmaceutical samples, blood samples, blood platelet samples, etc.) for the presence of bacteria (e.g., Gram-positive bacteria and/or Gram-negative bacteria), treat disorders associated with bacteria (e.g., Gram-positive bacteria and/or Gram-negative bacteria), and/or identify, sequester, and remove bacteria (e.g., Gram-positive bacteria and/or Gram-negative bacteria) from a liquid sample (e.g., water sample, food sample, pharmaceutical sample, blood sample, blood platelet sample, etc.). In certain embodiments, iron oxide nanoparticles are coated with dendrimer nano-particles conjugated with Vancomycin and/or Polymixin.
• FORMATION AND USE OF EMBEDDED SOLUTIONS IN NANOSCALE MATERIALS
  申请人：The Regents of the University of California

  公开号：US20180328921A1

  公开（公告）日：2018-11-15

  Provided herein are methods and materials that allow targeting and imaging of interactions between probes and targets. In some embodiments, the probes include nanoscale materials with embedded solutions that can be used to measure physical enhancement by materials under X-ray irradiation. In some embodiments, the methods of the present invention include delivering a probe material to a target that can have a delivered donor material. In some embodiments, methods of the present invention include irradiating the target and determining an optical change in the probe characteristic of a physical enhancement.
• 플루오레세인 유도체, 이의 제조방법 및 이를 이용한 pH 센서
  申请人：Kyungpook National University Industry-Academic Cooperation Foundation 경북대학교 산학협력단(220040016844) BRN ▼504-82-09678

  公开号：KR101922351B1

  公开（公告）日：2018-11-26

  본 발명은 플루오레세인 유도체, 이의 제조방법 및 이를 이용한 pH 센서를 제공하며, 상기 플루오레세인 유도체는 하기 화학식 1 또는 화학식 2로 나타낸다; [화학식 1] , [화학식 2]

  这项发明提供了一种氟螺酮衍生物、其制备方法以及pH传感器的使用，其中所述的氟螺酮衍生物由化学式1或化学式2表示; [化学式1]，[化学式2]。
• Ingraffia, Gazzetta Chimica Italiana, 1932, vol. 62, p. 781,789
  作者：Ingraffia

  DOI：——

  日期：——