2-hydroxy-3-oxo-2,3-diphenylpropanenitrile

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-hydroxy-3-oxo-2,3-diphenylpropanenitrile
• 英文别名: 2-Hydroxy-3-oxo-2,3-diphenylpropanenitrile
• 化学式: C₁₅H₁₁NO₂
• 分子量: 237.258
• InChiKey: SGYBJXCFPIYQTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  61.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  sodium cyanide 、 联苯甲酰 在 氧气 作用下， 以 乙腈 为溶剂， 反应 48.0h， 以50%的产率得到2-hydroxy-3-oxo-2,3-diphenylpropanenitrile
  参考文献：
  名称：

  Reduction of 1,2-dicarbonyl compounds and of their N-phenylimine derivatives by sodium cyanide under aprotic conditions

  摘要：

  摘要 一些芳香性1,2-二羰基化合物，即9,10-菲南酮、萘并醌和苯基乙酮及其相应的N-苯基单亚胺，已在存在氰化钠作为还原剂的情况下，使用干燥的乙腈作为溶剂进行还原。文中描述了比较静电测量法的制备规模电解。

  DOI：

  10.1016/j.crci.2015.07.007

文献信息

• QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS
  申请人：Aquila Brian

  公开号：US20090118261A1

  公开（公告）日：2009-05-07

  The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

  本发明涉及化学式(I)的化合物或其药学上可接受的盐，其具有B Raf抑制活性，因此对其抗癌活性有用，并且在人体或动物体的治疗方法中使用。本发明还涉及制造上述化学化合物的方法，包含它们的制药组合物以及在制造用于在温血动物（如人）中产生抗癌效果的药物中使用它们的用途。
• PROCESSES FOR PRODUCING CYANOPHENYL DERIVATIVES
  申请人：Showa Denko Kabushiki Kaisha

  公开号：EP1083165A1

  公开（公告）日：2001-03-14

  A process for producing a cyanobenzaldehyde compound which comprises using an oxidizing agent to convert the aminomethyl group of a cyanobenzylamine compound to an aldehyde group without impairing the cyano group; a process for producing a cyanobenzoyl halide compound which comprises converting the aldehyde group of a cyanobenzaldehyde compound to an acid halide group without impairing the cyano group; and a process for producing a cyanobenzoic acid compound which comprises reacting a cyanobenzaldehyde compound with a hypohalogenous acid. The cyanophenyl derivatives, useful as intermediates for medicines, agricultural chemicals, liquid crystals, functional high-molecular monomers, etc., can be efficiently produced from easily available materials.

  一种生产氰基苯甲醛化合物的工艺，其中包括使用一种氧化剂在不损害氰基的情况下将氰苄胺化合物的氨甲基基团转化为醛基团；生产卤代氰基苯甲酰基化合物的工艺，包括将氰基苯甲醛化合物的醛基转化为酸性卤化物基团而不损害氰基；以及生产氰基苯甲酸化合物的工艺，包括使氰基苯甲醛化合物与次卤酸反应。这些氰基苯基衍生物可用作药物、农药、液晶、功能性高分子单体等的中间体，可从容易获得的材料中有效地生产出来。
• Method for producing cyanophenyl derivatives
  申请人：SHOWA DENKO KABUSHIKI KAISHA

  公开号：EP1721891A1

  公开（公告）日：2006-11-15

  The invention relates to (1) a process for producing a cyanobenzaldehyde compound by converting the aminomethyl group in a cyanobenzylamine compound into an aldehyde group using an oxidizing agent without impairing the cyano group, to (2) a process for producing a cyanobenzoyl halide compound by converting the aldehyde group in a cyanobenzaldehyde compound into an acid halide group without impairing the cyano group, and to (3) a process for producing a cyanobenzoic acid compound by reacting a cyanobenzaldehyde compound with a hypohalogenous compound. According to the present invention, cyanophenyl derivatives that are useful as an intermediate of medical preparations, agricultural chemicals, liquid crystals, functional high molecular monomers and the like can be produced efficiently from raw materials that are obtained without difficulty.

  本发明涉及(1)利用氧化剂将氰苄胺化合物中的氨甲基转化为醛基，而不损害氰基，从而生产氰苯甲醛化合物的工艺、(2)在不损害氰基的情况下，通过将氰苯甲醛化合物中的醛基转化为酸性卤化基来生产氰苯甲酰化合物的工艺，以及(3)通过使氰苯甲醛化合物与次卤化合物反应来生产氰苯甲酸化合物的工艺。 根据本发明，可以从不难获得的原料中高效地生产出可用作医药制剂、农药、液晶、功能性高分子单体等中间体的氰基苯基衍生物。
• FOAM SURFACE CLEANER
  申请人：ECOLAB INC.

  公开号：EP0701599B1

  公开（公告）日：1997-09-10
• ALKALINE PEROXYGEN FOOD SOIL CLEANER
  申请人：Cummings Walter D.

  公开号：US20090288683A1

  公开（公告）日：2009-11-26

  The present invention relates to compositions and methods for removing soils, e.g., thermally degraded food soils, from surfaces. The cleaning compositions of the present invention can be activated using heat and/or an activator complex to generate oxygen gas in situ on and in the soil to be removed. Surfaces suitable for cleaning using the compositions and methods of the present invention include any surface that can be heated during use and/or cleaning, e.g., smokers, ovens, fryers.