2-Hydroxyxanthone-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-Hydroxyxanthone-3-carboxylic acid
• 英文别名: 2-Hydroxy-9-oxoxanthene-3-carboxylic acid
• 化学式: C₁₄H₈O₅
• 分子量: 256.215
• InChiKey: GGUKZFOVFGLAMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  碳酸乙烯酯 、 2-Hydroxyxanthone-3-carboxylic acid 在 sodium hydroxide 、 四丁基碘化铵 作用下， 以 乙醇 、 水 为溶剂， 生成 乙二醇甲醚
  参考文献：
  名称：

  Tetrazolyl substituted tricyclic compounds and pharmacological

  摘要：

  式（I）的三环化合物##STR1##其中X.sup.1是羧基或5-四唑基团，X.sup.2是酰基或亚甲基，X.sup.3是羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟

  公开号：

  US04902701A1

文献信息

• US4902701A
  申请人：——

  公开号：US4902701A

  公开（公告）日：1990-02-20
• Tetrazolyl substituted tricyclic compounds and pharmacological
  申请人：Burroughs Welcome Co.

  公开号：US04902701A1

  公开（公告）日：1990-02-20

  Tricyclic compounds of formula (I) ##STR1## wherein X.sup.1 is a carboxyl or 5-tetrazolyl group X.sup.2 is carbonyl or methylene X.sup.3 is hydroxyl or a group --X.sup.4 (C.sub.n H.sub.2n)X.sup.5 where X.sup.4 is oxygen or sulphur X.sup.5 is hydrogen or a group --OX.sup.6 where X.sup.6 is hydrogen, alkanoyl of 1 to 4 carbon atoms or a group --(C.sub.m H.sub.2m)X.sup.7 where X.sup.7 is hydrogen or a group --OX.sup.8 where X.sup.8 is hydrogen or alkanoyl of 1 to 4 carbon atoms and m and n are each, independently, an integer from 1 to 4, together with salts thereof, provided that when X.sup.5 is a group --OX.sup.6 then n is always greater than 1 and X.sup.4 and X.sup.5 are attached to different carbon atoms and that when X.sup.7 is a group --OX.sup.8 then m is always greater than 1 and no single carbon atom in the radical --(C.sub.m H.sub.2m)-- is attached to two oxygen atoms. These compounds are of value in medicine in circumstances where it is desirable to provide a more effective delivery of oxygen to the tissues; in vivo applications include the relief or amelioration of tissue hypoxia as in, for example, cardiac or cerebral ischaemia while in vitro they maintain the oxygen-delivery capacity of stored red blood cells and prolong the cells' useful storage life. The invention is also directed to methods for the preparation of the compounds, to pharmaceutical formulations and other presentation forms containing them and the preparation thereof, to the use of the compound in medicine, and to novel intermediates for the said compounds and the preparation thereof.

  式（I）的三环化合物##STR1##其中X.sup.1是羧基或5-四唑基团，X.sup.2是酰基或亚甲基，X.sup.3是羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟基或羟