2-methyl-1,4-napthohydroquinone

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-methyl-1,4-napthohydroquinone
• 英文别名: 4-hydroxy-3-methyl-4H-naphthalen-1-one
• 化学式: C₁₁H₁₀O₂
• 分子量: 174.199
• InChiKey: CFAWWQIGBCWYLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  di-tert-butyliminoxyl 、 2-methyl-1,4-napthohydroquinone 以92%的产率得到甲萘醌
  参考文献：
  名称：

  Free-radical reagents. 2. Oxidation and addition products from the reaction of di-tert-butyliminoxyl with phenols

  摘要：

  DOI：

  10.1021/jo00376a061

文献信息

• Inhibition of tau-tau-association
  申请人：Wischik Michel Claude

  公开号：US20070191352A1

  公开（公告）日：2007-08-16

  A composition and use thereof for the prophylaxis or treatment of Alzheimer's disease, motor neurone disease, Lewy body disease, Pick's disease or progressive supranuclear palsy. The composition includes an agent which modulates or inhibits tau-tau association and which does not inhibit tau-tubulin binding. In the method the agent is administered to an individual in order to achieve the desired therapeutic effect. Preferably the agent which is administered is a phenothiazine compound.
• US8278298B2
  申请人：——

  公开号：US8278298B2

  公开（公告）日：2012-10-02
• Free-radical reagents. 2. Oxidation and addition products from the reaction of di-tert-butyliminoxyl with phenols
  作者：M. Ngo、K. R. Larson、G. D. Mendenhall

  DOI：10.1021/jo00376a061

  日期：1986.12