Aminoglycoside derivatives, processes for their preparation and pharmaceutical compositions containing them
申请人:FUJISAWA PHARMACEUTICAL CO., LTD.
公开号:EP0107850A1
公开(公告)日:1984-05-09
Aminoglycoside derivatives of the formula:
wherein at least one of R', R2, R3 and R4 is higher alkanoylamino, higher alkenoylamino, higher alkoxycarbonylamino, higher alkylaminocarbonylamino, higher alkoxy(lower)alkanoylamino or higher alkylthiocarbonyrm- no, each of which may have suitable substituent(s), and the others are amino or acylamino,
R5 is hydroxy, amino or acylamino, R6 and R7 are each hydroxy or hydrogen, and R10 is hydroxy or phosphonoxy, and pharmaceutically acceptable salts thereof, processes for their preparations and pharmaceutical compositions containing them. The invention further relates to intermediates for preparing such compounds and processes for their preparation.
式中的氨基糖苷衍生物:
其中 R'、R2、R3 和 R4 中至少有一个是高级烷酰基氨基、高级烯酰基氨基、高级烷氧基羰基氨基、高级烷基氨基羰基氨基、高级烷氧基(低级)烷酰基氨基或高级烷基硫代羰基氨基,每一个都可以有合适的取代基,其他的是氨基或酰基氨基、
R5是羟基、氨基或酰氨基,R6和R7各自是羟基或氢,R10是羟基或磷酰氧基,以及它们的药学上可接受的盐、它们的制备工艺和含有它们的药物组合物。本发明还涉及制备此类化合物的中间体及其制备工艺。