二十烷-1-基硫酸氢酯 | 67633-89-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 中文名称: 二十烷-1-基硫酸氢酯
• 英文名称: 1-Eicosanol, hydrogen sulfate
• 英文别名: icosyl hydrogen sulfate
• CAS: 67633-89-0
• 化学式: C₂₀H₄₂O₄S
• 分子量: 378.6
• InChiKey: DLFKFFZPKVOYJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.1
• 重原子数：
  25
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  72
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Stabile topische Formulierungen mit gutem Wirkstoff-Freisetzungsvermögen enthaltend mindestens ein lipophilisiertes Makrolidantibiotikum
  申请人：Röhm Pharma GmbH

  公开号：EP0592904A1

  公开（公告）日：1994-04-20

  Die Erfindung betrifft die Lipophilisierung von Makrolidantibiotika, insbesondere von Erythromycin und dessen Derivaten, mit Gegenionenbildnern, die einen oder mehrere lineare und/oder verzweigte Alkylsubstituenten mit 6 bis 32 Kohlenstoffatomen besitzen. Mit den Komplexen aus Makrolidantibiotikum und Gegenionenbildner werden stabile, bevorzugt halbfeste Formulierungen für topische Anwendungen mit einem guten Wirkstoff-Freisetzungsverhalten möglich. Bevorzugt weisen die Gegenionenbildner Alkylreste mit 12 bis 32 Kohlenstoffatomen und als ionenbildende Gruppen Sulfat-, Sulfonat- oder Salicylat-Gruppen auf.

  本发明涉及大环内酯类抗生素（尤其是红霉素及其衍生物）与反离子形成剂的亲脂化，反离子形成剂具有一个或多个6至32个碳原子的直链和/或支链烷基取代基。大环内酯类抗生素与反离子形成剂的复合物可制成稳定的、优选的半固体制剂，用于局部应用，并具有良好的药物释放性能。反离子形成剂最好具有 12 至 32 个碳原子的烷基和作为离子形成基团的硫酸根、磺酸根或水杨酸根。
• COMPOSITION FOR HYDROPHILIC CURED PRODUCT
  申请人：Mitsui Chemicals, Inc.

  公开号：EP3081578A1

  公开（公告）日：2016-10-19

  Objects of the present invention are to provide a composition which can easily give cured products enriched with hydrophilic groups at the surface, and a composition which can give cured products while ensuring that the surface is enriched with hydrophilic groups which are hardly concentrated at the surface by conventional methods; to provide cured products obtained from such compositions; to provide a composition which is suited for producing cured products having high and long-lasting hydrophilicity and also having high surface smoothness; and to provide a cured product obtained from the composition. A monolayer film is fabricated which includes a crosslinked resin obtained by polymerizing a composition including a compound (I) having at least one hydrophilic group selected from anionic hydrophilic groups, cationic hydrophilic groups and hydroxyl groups, and at least one functional group with a polymerizable carbon-carbon double bond (wherein the number of the functional groups with a polymerizable carbon-carbon double bond is one when the hydrophilic group is a hydroxyl-containing group); a compound (II) having two or more functional groups with a polymerizable carbon-carbon double bond (wherein the compound may have a hydroxyl group but is free from anionic hydrophilic groups and cationic hydrophilic groups); and at least one compound selected from a surfactant (III) having a hydrophilic moiety including an anionic hydrophilic group, a cationic hydrophilic group or two or more hydroxyl groups, and a hydrophobic moiety including an organic residue, and a compound (IV) having a siloxane bond and a molecular weight of 200 to 1,000,000 (wherein the surfactant (III) and the compound (IV) have no polymerizable carbon-carbon double bonds). The monolayer film has a gradient of hydrophilic group concentration (Sa/Da) of not less than 1.1 wherein Sa is the surface concentration of at least one type of hydrophilic groups selected from anionic hydrophilic groups, cationic hydrophilic groups and hydroxyl groups, and Da is the deep concentration of the hydrophilic groups at 1/2 of the thickness of the monolayer film.

  本发明的目的是提供一种组合物，该组合物可以很容易地得到表面富含亲水基团的固化产品，以及一种组合物，该组合物可以在得到固化产品的同时确保表面富含亲水基团，而通过传统方法，亲水基团很难集中在表面上；提供由这种组合物得到的固化产品；提供一种组合物，该组合物适合生产具有高且持久亲水性的固化产品，同时还具有高表面光滑度；以及提供由该组合物得到的固化产品。本发明制备了一种单层膜，该单层膜包括通过聚合一种组合物而获得的交联树脂，该组合物包括一种化合物 (I)，该化合物具有至少一个亲水基团，该亲水基团选自阴离子亲水基团、阳离子亲水基团和羟基，以及至少一个具有可聚合碳碳双键的官能团（其中当亲水基团为含羟基基团时，具有可聚合碳碳双键的官能团的数目为一个）；具有两个或两个以上具有可聚合碳碳双键的官能团的化合物 (II)（其中该化合物可具有羟基，但不含阴离子亲水基团和阳离子亲水基团）；以及至少一种选自表面活性剂（III）的化合物，该表面活性剂具有包括阴离子亲水基团、阳离子亲水基团或两个或多个羟基在内的亲水分子，以及包括有机残留物在内的疏水分子，以及具有硅氧烷键且分子量在 200-1,000,000 之间的化合物（IV）（其中表面活性剂（III）和化合物（IV）不具有可聚合的碳碳双键）。单层膜的亲水基团浓度梯度（Sa/Da）不小于 1.1，其中 Sa 是选自阴离子亲水基团、阳离子亲水基团和羟基的至少一种亲水基团的表面浓度，Da 是亲水基团在单层膜厚度的 1/2 处的深度浓度。
• PRODUCTION METHOD FOR ORGANOPOLYSILOXANE EMULSION COMPOSITION
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP3345957A1

  公开（公告）日：2018-07-11

  A production method for an organopolysiloxane emulsion composition, wherein (I) an emulsion composition is prepared from an organopolysiloxane (A) that is represented by formula (1) and that has an octamethylcyclotetrasiloxane content of 1,000 ppm or less         HO(R12SiO)nH     (1), (wherein R1 is H or a monovalent hydrocarbon group and n is a number that makes the viscosity, at 25°C, of the organopolysiloxane 200 mm2/s or more but less than 2,000 mm2/s), a surfactant (B) that is represented by formula (2) and that has an alkyl naphthalene skeleton         R2a-C10H(7-a)-SO3M     (2), (wherein R2 is an alkyl group, M is H+, an alkali metal ion, an alkali earth metal ion, NH4+, or a tertiary NH4+, and m is 1-3), and water (C-1), and wherein (II) water (C-2) is added as necessary and then emulsion polymerization is performed in the presence of an acid catalyst (D). The organopolysiloxane produced has a viscosity of 300,000 mPa·s or higher at 25°C and has an octamethylcyclotetrasiloxane content of 3,000 ppm or less. The particle size of the emulsion is 500 nm or less.

  一种有机聚硅氧烷乳液组合物的生产方法，其中 (I) 由式（1）表示的有机聚硅氧烷（A）制备乳液组合物，该有机聚硅氧烷的八甲基环四硅氧烷含量为 1,000 ppm 或以下 HO(R12SiO)nH (1)、 (其中 R1 是 H 或一价烃基，n 是使有机聚硅氧烷在 25°C 时的粘度达到或超过 200 mm2/s 但小于 2,000 mm2/s 的数值），由式（2）表示的表面活性剂（B），其骨架为烷基萘 R2a-C10H(7-a)-SO3M (2)、 (其中 R2 为烷基，M 为 H+、碱金属离子、碱土金属离子、NH4+ 或三级 NH4+，m 为 1-3）和水 (C-1)，其中 (II) 必要时加入水 (C-2)，然后在酸催化剂 (D) 存在下进行乳液聚合。生产出的有机聚硅氧烷在 25°C 时的粘度为 300,000 mPa-s 或更高，八甲基环四硅氧烷含量为 3,000 ppm 或更低。乳液的粒径为 500 nm 或更小。
• Emulsified fatty acids
  申请人：BARLEAN'S ORGANIC OILS, LLC

  公开号：US10117832B2

  公开（公告）日：2018-11-06

  Provided herein are methods and processes for emulsifying non-polar compounds, such as omega fatty acids. Also provided are compositions that can be prepared according to the methods and processes described herein. The compositions, for example, have a high amount of the non-polar compound, such as a large amount of omega fatty acids. The non-polar compounds are also present in very small droplets within composition. For example, the mean or median particle size of the droplets is less than about 5 μm. Further, the composition includes a low amount of surfactant, such as less than about 10-15% of the surfactant.

  本文提供了乳化非极性化合物（如欧米茄脂肪酸）的方法和工艺。还提供了可根据本文所述方法和工艺制备的组合物。例如，这些组合物含有大量非极性化合物，如大量欧米伽脂肪酸。非极性化合物还以极小的液滴形式存在于组合物中。例如，液滴的平均粒径或中值粒径小于约 5 μm。此外，组合物中的表面活性剂含量较低，例如低于约 10-15% 的表面活性剂。
• Production method for organopolysiloxane emulsion composition
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US10870734B2

  公开（公告）日：2020-12-22

  A production method for an organopolysiloxane emulsion composition, wherein (I) an emulsion composition is prepared from an organopolysiloxane (A) that is represented by formula (1) and that has an octamethylcyclotetrasiloxane content of 1,000 ppm or less HO(R12SiO)nH  (1), (wherein R1 is H or a monovalent hydrocarbon group and n is a number that makes the viscosity, at 25° C., of the organopolysiloxane 200 mm2/s or more but less than 2,000 mm2/s), a surfactant (B) that is represented by formula (2) and that has an alkyl naphthalene skeleton R2a—C10H(7-a)—SO3M  (2), (wherein R2 is an alkyl group, M is H+, an alkali metal ion, an alkali earth metal ion, NH4+, or a tertiary NH4+, and m is 1-3), and water (C-1), and wherein (II) water (C-2) is added as necessary and then emulsion polymerization is performed in the presence of an acid catalyst (D).

  一种有机聚硅氧烷乳液组合物的生产方法，其中 (I) 由式（1）表示的有机聚硅氧烷（A）制备乳液组合物，该有机聚硅氧烷的八甲基环四硅氧烷含量为 1,000 ppm 或以下 HO(R12SiO)nH (1)、 (其中 R1 为 H 或一价烃基，n 为使有机聚硅氧烷在 25 摄氏度时的粘度为 200 平方毫米/秒或以上但小于 2,000 平方毫米/秒的数值）、由式（2）表示且具有烷基萘骨架的表面活性剂（B）； - 由式（3）表示且具有烷基萘骨架的表面活性剂（B）； - 由式（4）表示且具有烷基萘骨架的表面活性剂（B）； - 由式（5）表示且具有烷基萘骨架的表面活性剂（B）。 R2a-C10H(7-a)-SO3M (2)、 (其中 R2 为烷基，M 为 H+、碱金属离子、碱土金属离子、NH4+ 或三级 NH4+，m 为 1-3）和水 (C-1)，其中 (II) 必要时加入水 (C-2)，然后在酸催化剂 (D) 存在下进行乳液聚合。