(E)-5-((2-(2,4-dinitrophenyl)hydrazono)methyl)-2-methoxyphenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (E)-5-((2-(2,4-dinitrophenyl)hydrazono)methyl)-2-methoxyphenol
• 英文别名: 5-[(E)-[(2,4-dinitrophenyl)hydrazinylidene]methyl]-2-methoxyphenol
• 化学式: C₁₄H₁₂N₄O₆
• 分子量: 332.272
• InChiKey: NLGSYZHLKMBOTB-OVCLIPMQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  146
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (E)-5-((2-(2,4-dinitrophenyl)hydrazono)methyl)-2-methoxyphenol 在 sodium azide 作用下， 以 水 为溶剂， 反应 4.0h， 以83%的产率得到4-((2,4-dinitrophenyl)amino)-4,5-dihydro-1H-tetrazol-1-yl-2-methoxyphenol
  参考文献：
  名称：

  Synthesis and Characterization of Novel Five-Membered Heterocycles and Their Activity against Candida Yeasts

  摘要：

  Some new tetrazole derivatives were prepared by the reaction between the prepared azomethine compounds I-6-I-10 with sodium azide in anhydrous tetrahydrofuran (THF) with a few drops of distilled water and under reflux conditions. Azomethine compounds were prepared by thermal condensation reactions of aromatic aldehydes with primary aromatic amines. The prepared compounds (tetrazole derivatives) were screened for their antibacterial activity (by disc diffusion method). Compound I-6 is the most active derivative that has recorded a significantly (p<0.01) stronger influence to inhibit the growth of Candida zeylanoides with an average zone of inhibition of 26.0 mm. Derivatives I-7 and I-9 showed the lowest zone of inhibition of 8.0 mm against Candida zeylanoides. This study may be helpful in designing more potential anticandidal agents for therapeutic use in the future.

  DOI：

  10.17344/acsi.2018.4719
• 作为产物：
  描述：

  异香兰素 、 2,4-二硝基苯肼 以 乙醇 为溶剂， 反应 3.0h， 以90%的产率得到
  参考文献：
  名称：

  From Dynamic Combinatorial Chemistry to in Vivo Evaluation of Reversible and Irreversible Myeloperoxidase Inhibitors

  摘要：

  The implementation of dynamic combinatorial libraries allowed the determination of highly active reversible and irreversible inhibitors of myeloperoxidase (MPO) at the nanomolar level. Docking experiments highlighted the interaction between the most active ligands and MPO, and further kinetic studies defined the mode of inhibition of these compounds. Finally, in vivo evaluation showed that one dose of irreversible inhibitors is able to suppress the activity of MPO after inducing inflammation.

  DOI：

  10.1021/acsmedchemlett.6b00417

文献信息

• From Dynamic Combinatorial Chemistry to <i>in Vivo</i> Evaluation of Reversible and Irreversible Myeloperoxidase Inhibitors
  作者：Jalal Soubhye、Michel Gelbcke、Pierre Van Antwerpen、François Dufrasne、Mokhtaria Yasmina Boufadi、Jean Nève、Paul G. Furtmüller、Christian Obinger、Karim Zouaoui Boudjeltia、Franck Meyer

  DOI：10.1021/acsmedchemlett.6b00417

  日期：2017.2.9

  The implementation of dynamic combinatorial libraries allowed the determination of highly active reversible and irreversible inhibitors of myeloperoxidase (MPO) at the nanomolar level. Docking experiments highlighted the interaction between the most active ligands and MPO, and further kinetic studies defined the mode of inhibition of these compounds. Finally, in vivo evaluation showed that one dose of irreversible inhibitors is able to suppress the activity of MPO after inducing inflammation.
• Synthesis and Characterization of Novel Five-Membered Heterocycles and Their Activity against Candida Yeasts
  作者：Hiba Maher Tawfeeq、Rasim Farraj Muslim、Obaid Hasan Abid、Mustafa Nadhim Owaid

  DOI：10.17344/acsi.2018.4719

  日期：——

  Some new tetrazole derivatives were prepared by the reaction between the prepared azomethine compounds I-6-I-10 with sodium azide in anhydrous tetrahydrofuran (THF) with a few drops of distilled water and under reflux conditions. Azomethine compounds were prepared by thermal condensation reactions of aromatic aldehydes with primary aromatic amines. The prepared compounds (tetrazole derivatives) were screened for their antibacterial activity (by disc diffusion method). Compound I-6 is the most active derivative that has recorded a significantly (p<0.01) stronger influence to inhibit the growth of Candida zeylanoides with an average zone of inhibition of 26.0 mm. Derivatives I-7 and I-9 showed the lowest zone of inhibition of 8.0 mm against Candida zeylanoides. This study may be helpful in designing more potential anticandidal agents for therapeutic use in the future.