(P,2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-[2-((E)-1-carboxy-2-(3,4-dihydroxyphenyl)ethenyl)-3,4-dihydroxyphenyl]prop-2-enoyl]oxypropanoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (P,2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-[2-((E)-1-carboxy-2-(3,4-dihydroxyphenyl)ethenyl)-3,4-dihydroxyphenyl]prop-2-enoyl]oxypropanoic acid
• 英文别名: salvianolic acid T；2-[(E)-3-[2-[(E)-1-carboxy-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoic acid
• 化学式: C₂₇H₂₂O₁₂
• 分子量: 538.464
• InChiKey: SCMZYGMTIITQCA-SDQFYIDFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  222
• 氢给体数：
  8
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  (P,2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-[2-((E)-1-carboxy-2-(3,4-dihydroxyphenyl)ethenyl)-3,4-dihydroxyphenyl]prop-2-enoyl]oxypropanoic acid 在 盐酸 、 水 作用下， 生成 丹参素 、 (E)-2-(6-((E)-2-carboxyvinyl)-2,3-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)acrylic acid
  参考文献：
  名称：

  Salvianolic acids T and U: A pair of atropisomeric trimeric caffeic acids derivatives from root of Salvia miltiorrhiza

  摘要：

  Two new trimeric caffeic acids, named salvianolic acids T and U (1 and 2), were isolated from the underground part of Salvia miltiorrhiza. Their structures, consisting of three caffeic acid units, were determined based on extensive 1D- and 2D-spectroscopic analyses and electronic circular dichroism (ECD) calculations. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.fitote.2014.08.018

文献信息

• TRADITIONAL CHINESE MEDICINE COMPOSITION, AND PREPARATION AND APPLICATION THEREOF
  申请人：TASLY PHARMACEUTICAL GROUP CO., LTD.

  公开号：US20160175336A1

  公开（公告）日：2016-06-23

  A traditional Chinese medicine composition for treating cardiovascular disease, and a preparation thereof, particularly a micro drop pill preparation thereof, and a method for preparing the preparation; the method for preparing the micro drop pill preparation can be used to prepare drop pills, coated drop pills, and drop pill capsules with a high drug loading capacity.

  一种传统中药组合物，用于治疗心血管疾病，以及其制备方法，特别是微滴丸制备方法，以及制备方法；制备微滴丸制剂的方法可用于制备具有高药物负载能力的滴丸，包衣滴丸和滴丸胶囊。
• Traditional Chinese medicine composition
  申请人：Tasly Pharmaceutical Group Co., Ltd.

  公开号：US10300030B2

  公开（公告）日：2019-05-28

  A traditional Chinese medicine composition and preparation thereof for treating cardiovascular diseases is provided. The traditional Chinese medicine composition consists of: by weight percentage, phenolic acid derivatives 30%˜80%, tanshinones 2%˜10% and saponins 15%˜60%.

  本发明提供了一种治疗心血管疾病的中药组合物及其制剂。该中药组合物包括：按重量百分比计，酚酸衍生物 30%˜80%，丹参酮 2%˜10%，皂苷 15%˜60%。
• Salvianolic acid compound T, preparation method therefor, and use thereof
  申请人：TASLY PHARMACEUTICAL GROUP CO., LTD.

  公开号：US10626077B2

  公开（公告）日：2020-04-21

  The present invention relates to the medical field, specifically a salvianolic acid T as described in structural formula (I), a chiral isomer thereof, a preparation method therefor, pharmaceutical compositions, antioxidants, and free radical scavengers thereof, and a use of the compound.

  本发明涉及医药领域，具体是一种结构式（I）所述的丹酚酸 T、其手性异构体、其制备方法、其药物组合物、抗氧化剂和自由基清除剂以及该化合物的用途。
• TRADITIONAL CHINESE MEDICINE COMPOSITION
  申请人：TASLY PHARMACEUTICAL GROUP CO., LTD.

  公开号：US20160184249A1

  公开（公告）日：2016-06-30

  A traditional Chinese medicine composition and preparation thereof for treating cardiovascular diseases is provided. The traditional Chinese medicine composition consists of: by weight percentage, phenolic acid derivatives 30%˜80%, tanshinones 2%˜10% and saponins 15%˜60%.
• NEW SALVIANOLIC ACID COMPOUND T, PREPARATION METHOD THEREFOR, AND USE THEREOF
  申请人：TASLY PHARMACEUTICAL GROUP CO., LTD.

  公开号：US20160200661A1

  公开（公告）日：2016-07-14

  The present invention relates to the medical field, specifically a salvianolic acid T as described in structural formula (I), a chiral isomer thereof, a preparation method therefor, pharmaceutical compositions, antioxidants, and free radical scavengers thereof, and a use of the compound.