2-hydroxy-5-(4-(trifluoromethyl)phenylethylamino)benzoic acid

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-hydroxy-5-(4-(trifluoromethyl)phenylethylamino)benzoic acid
• 英文别名: 5-[N-ethyl-4-(trifluoromethyl)anilino]-2-hydroxybenzoic acid
• 化学式: C₁₆H₁₄F₃NO₃
• 分子量: 325.287
• InChiKey: KNIXAJOTSYQZDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Pharmaceutical Composition for Treating or Preventing Degenerative and Inflammatory Diseases
  申请人：GWAG Byoung-Joo

  公开号：US20090240079A1

  公开（公告）日：2009-09-24

  The present invention relates to a pharmaceutical composition useful for treating or preventing inflammatory disease and cell damage, and a method for treating or preventing inflammatory disease and cell damage. The present invention uses the 2-hydroxybenzoic acid derivative represented by the specific chemical formula or its pharmaceutically acceptable salt. The compound of the present invention is useful for treating or preventing cell damage and inflammatory disease including gastritis, gastric ulcer, pancreatitis, colitis, arthritis, diabetes, arteriosclerosis, nephritis, hepatitis, Alzheimer's disease, Parkinson's disease and Lou Gehrig's disease.

  本发明涉及一种用于治疗或预防炎症性疾病和细胞损伤的药物组合物，以及一种用于治疗或预防炎症性疾病和细胞损伤的方法。本发明使用由特定化学式表示的2-羟基苯甲酸衍生物或其药用可接受的盐。本发明的化合物对治疗或预防包括胃炎、胃溃疡、胰腺炎、结肠炎、关节炎、糖尿病、动脉硬化、肾炎、肝炎、阿尔茨海默病、帕金森病和路易·盖里格病在内的细胞损伤和炎症性疾病有益。
• PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING DEGENERATIVE AND INFLAMMATORY DISEASES
  申请人：Neurotech Co., Ltd.

  公开号：EP2004164A1

  公开（公告）日：2008-12-24
• PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING INFLAMMATORY DISEASES
  申请人：Neurotech Pharmaceuticals Co., Ltd.

  公开号：EP2004164B1

  公开（公告）日：2018-08-08
• Combination Therapy for Neuroprotection
  申请人：Yoon Sung-Hwa

  公开号：US20100216749A1

  公开（公告）日：2010-08-26

  The present invention relates to combination therapy of a pyruvoyl derivative and an anti-oxidant, which is characterized by significant increase of the activity of microglia, inhibition of brain tissue damage by the activation of inflammatory cytokines, improvement of motor skill and recovery effect of neuronal damage. Compared to single treatment with each, this present invention provides a continuous high neuroprotective effect even after 6 hours from the onset of damage.
• US8455470B2
  申请人：——

  公开号：US8455470B2

  公开（公告）日：2013-06-04