N-(dodecyl)sulfamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: N-(dodecyl)sulfamide
• 英文别名: N-dodecylsulfamide；1-(sulfamoylamino)dodecane
• 化学式: C₁₂H₂₈N₂O₂S
• 分子量: 264.433
• InChiKey: IIPAGVRUKBRFKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  80.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(dodecyl)sulfamide 、 (1R)-1,2,3,4-tetra-O-acetyl-5N,6O-oxomethylidenenojirimycin 在 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 以78 %的产率得到
  参考文献：
  名称：

  WO2023/73005

  摘要：

  公开号：
• 作为产物：
  描述：

  十二烷基伯胺 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 32.5h， 生成 N-(dodecyl)sulfamide
  参考文献：
  名称：

  Synthesis of arabinose glycosyl sulfamides as potential inhibitors of mycobacterial cell wall biosynthesis

  摘要：

  A series of arabinose glycosyl sulfamides with varying alkyl chain types and lengths were synthesised as mimics of decaprenolphosphoarabinose (DPA), and as potential inhibitors of mycobacterial cell wall biosynthesis. Unprecedented conversion of the desired furanose to the thermodynamically more stable pyranose form occurred during final de-protection. Biological testing against Mycobacterium smegmatis revealed low to moderate anti-mycobacterial activity with marked dependence on alkyl chain length, which in the case of mono-substituted sulfamides was maximal for a C-10 chain. (C) 2015 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2015.07.050

文献信息

• [EN] COLORANT MULTIMER, COLORED CURABLE COMPOSITION, COLOR FILTER AND METHOD FOR PRODUCING THE SAME, AND SOLID-STATE IMAGE SENSOR, IMAGE DISPLAY DEVICE, LIQUID CRYSTAL DISPLAY DEVICE AND ORGANIC EL DISPLAY WITH THE COLOR FILTER<br/>[FR] MULTIMÈRE COLORANT, COMPOSITION DURCISSABLE COLORÉE, FILTRE COLORÉ ET PROCÉDÉ DE FABRICATION DE CEUX-CI, ET DÉTECTEUR D'IMAGES À L'ÉTAT SOLIDE, DISPOSITIF D'AFFICHAGE D'IMAGES, DISPOSITIF D'AFFICHAGE À CRISTAUX LIQUIDES ET DISPOSITIF D'AFFICHAGE ÉLEC
  申请人：FUJIFILM CORP

  公开号：WO2011040628A1

  公开（公告）日：2011-04-07

  A colorant multimer includes, as a partial structure of a colorant moiety, a dipyrromethene metal complex compound or tautomer thereof obtained from: (i) a dipyrromethene compound represented by the following Formula (M); and (ii) a metal or a metal compound: wherein in Formula (M), R4, R5, R6, R7, R8, R9, and R10 each independently represent a hydrogen atom or a monovalent substituent.

  一种着色剂多聚体包括作为着色剂部分结构的二吡咯甲烷金属配合物化合物或其互变异构体，所述化合物由以下公式（M）表示的二吡咯甲烷化合物和金属或金属化合物得到：其中在公式（M）中，R4、R5、R6、R7、R8、R9和R10分别独立地表示氢原子或一价取代基。
• Synthesis and anti-mycobacterial activity of glycosyl sulfamides of arabinofuranose
  作者：Kajitha Suthagar、Antony J. Fairbanks

  DOI：10.1039/c5ob02317c

  日期：——

  A series of arabino N-glycosyl sulfamides, forced to adopt the furanose form by removal of the 5-hydroxyl group, were synthesised as putative isosteric mimics of decaprenolphosphoarabinose, the donor processed by arabinosyltransferases during mycobacterial cell wall assembly. Compounds showed moderate anti-mycobacterial activity, which was maximal for a C10 sulfamide side chain.

  合成了一系列阿拉伯糖N-糖基磺酰胺，通过去除5-羟基来强制采用呋喃糖形式，作为癸癸醇磷酸阿拉伯糖的假定等规模拟物，其是在分枝杆菌细胞壁组装过程中由阿拉伯糖基转移酶处理的供体。化合物显示出中等的抗分枝杆菌活性，这对于C 10磺酰胺侧链是最大的。
• Acyclic Sulfamide Derivatives
  申请人：Rodriguez De Fonseca Fernando Antonio

  公开号：US20090221710A1

  公开（公告）日：2009-09-03

  The present invention is related to acyclic sulfamide derivatives, useful for the manufacture of a medicament for satiety induction and ingestion control, corporal fat modulation and lipidic metabolism regulation and for the manufacture of a medicament for the treatment or prevention of diabetes and cardiovascular diseases. The acyclic sulfamide derivatives are also useful for cosmetic use.

  本发明涉及无环磺酰胺衍生物，用于制造诱导饱腹感和控制摄入量、调节体内脂肪和脂质代谢的药物，以及用于制造治疗或预防糖尿病和心血管疾病的药物。无环磺酰胺衍生物还可用于化妆品。
• Silver halide color photographic material
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0524540A1

  公开（公告）日：1993-01-27

  A silver halide color photographic material comprises a combination of at least one yellow dye-forming coupler of the following general formula (1) with at least one discoloration inhibitor of special amide, phosphorus or hydrazine compound type to prevent the dye images, especially the yellow dye image, formed therein from discoloring or changing their colors; wherein X³ represents an organic residue completing a nitrogen-containing heterocyclyl group together with 〉N-; Y represents an aromatic or heterocyclic group; and Z represents a group capable of splitting off when the coupler represented by the foregoing formula reacts with the oxidation product of an aromatic primary amine color developing agent.

  一种卤化银彩色感光材料包括至少一种下式（1）的黄色染料形成耦合剂与至少一种特殊酰胺、磷或肼化合物类型的变色抑制剂的组合，以防止其中形成的染料图像，特别是黄色染料图像变色或改变其颜色； 其中 X³ 代表有机残基，与〉N-一起完成含氮杂环基团；Y 代表芳香族或杂环基团；Z 代表当前述式子所代表的耦合剂与芳香族伯胺显色剂的氧化产物反应时能够分裂的基团。
• Novel Sulfamide Analogs of Oleoylethanolamide Showing In Vivo Satiety Inducing Actions and PPARα Activation
  作者：Carolina Cano、Javier Pavón、Antonia Serrano、Pilar Goya、Juan Antonio Paez、Fernando Rodriguez de Fonseca、Manuel Macias-Gonzalez

  DOI：10.1021/jm0601102

  日期：2007.1.1

  Long chain saturated and unsaturated alkyl sulfamide and propyl sulfamide derivatives, analogs of oleoylethanolamide, have been synthesized and evaluated in vivo and in vitro as peroxisome proliferator activated receptor alpha (PPAR alpha) activators. Additionally, the anorexic effects of the new compounds have been studied in vivo in food-deprived rats. Among the active compounds N-octadecyl-N'-propylsulfamide (7) has been identified as a potent hypolipidemic compound, a potent feeding suppressant, and a concentration-dependent activator of PPAR alpha.