2-(1,4-diazepan-1-yl)-3H-quinazolin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(1,4-diazepan-1-yl)-3H-quinazolin-4-one
• 化学式: C₁₃H₁₆N₄O
• 分子量: 244.29
• InChiKey: DOIHLOLEXPEFFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  56.7
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Substituted quinazoline compounds and preparation and uses thereof
  申请人：Sunshine Lake Pharma Co., Ltd.

  公开号：US10196383B2

  公开（公告）日：2019-02-05

  The present invention relates quinazolinone compounds of Formula (I), as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses; wherein the compounds or pharmaceutical compositions disclosed herein can be used for antagonizing the orexin receptor. The present invention also relates to uses of the compounds or pharmaceutical compositions in treating or preventing neurological and psychiatric disorders and diseases of the central nervous system in mammals, especially in humans.

  本发明涉及式(I)的喹唑啉酮化合物及其制备方法和用途，并进一步涉及包含这些化合物的药物组合物及其用途；其中本文公开的化合物或药物组合物可用于拮抗奥曲肽受体。本发明还涉及这些化合物或药物组合物在治疗或预防哺乳动物，特别是人类的神经和精神紊乱以及中枢神经系统疾病中的用途。
• SUBSTITUTED QUINAZOLINE COMPOUNDS AND PREPARATION AND USES THEREOF
  申请人：Sunshine Lake Pharma Co., Ltd.

  公开号：US20180215737A1

  公开（公告）日：2018-08-02

  The present invention relates quinazolinone compounds of Formula (I), as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses; wherein the compounds or pharmaceutical compositions disclosed herein can be used for antagonizing the orexin receptor. The present invention also relates to uses of the compounds or pharmaceutical compositions in treating or preventing neurological and psychiatric disorders and diseases of the central nervous system in mammals, especially in humans.