Enterally effective biologically active peptide or protein composition, method for the production thereof, and a pharmaceutical composition containing same
申请人:Research Corporation
公开号:EP0198388A2
公开(公告)日:1986-10-22
A complex of a therapeutic agent is disclosed in which the therapeutic agent is complexed to an ammonium ion selected from the group consisting of
where R' and R2 are the same or different and are alkyl or hydroxy substituted alkyl containing 1 to 6 carbon atoms; and R, R' and R" are the same or different and are saturated or unsaturated aliphatics containing at least 10 carbon atoms,
wherein R', R2 and R' ' are as defined above,
where R3 is independently alkyl or hydroxy substituted alkyl containing at least 10 carbon atoms; and R', R2, R3 and R and R' have the meanings given above; and
where R', R2 and R3 have the meanings given above. The therapeutic agent is heparin, a biologically active peptide or protein or an antineoplastic drug. The therapeutic agent may also be covalently bonded to a triglyceride type backbone to form a compound. The compound thus formed has a structural formula selected from the group consisting of
where R and R' are the same or different and are saturated or unsaturated aliphatic containing at least 10 carbon atoms; and
本发明公开了一种治疗剂络合物,其中治疗剂与选自以下组别的铵离子络合
其中 R'和 R2 相同或不同,且为含有 1 至 6 个碳原子的烷基或羟基取代的烷基; R、R'和 R "相同或不同,且为含有至少 10 个碳原子的饱和或不饱和脂肪族、
其中 R'、R2 和 R' ' 如上定义、
其中 R3 独立地是至少含 10 个碳原子的烷基或羟基取代的烷基;且 R'、R2、R3 和 R 和 R' 具有上述含义;以及
其中 R'、R2 和 R3 具有上述含义。治疗剂是肝素、生物活性肽或蛋白质或抗肿瘤药物。治疗剂也可以与甘油三酯类骨架共价键合形成化合物。由此形成的化合物的结构式选自以下一组
其中 R 和 R'相同或不同,并且是含有至少 10 个碳原子的饱和或不饱和脂肪族;以及