2-chloro-6,7-dimethoxy-N-[(3R)-piperidin-3-yl]quinazolin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-chloro-6,7-dimethoxy-N-[(3R)-piperidin-3-yl]quinazolin-4-amine
• 化学式: C₁₅H₁₉ClN₄O₂
• 分子量: 322.79
• InChiKey: HTLLPJPVWDLXDC-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  68.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] HETEROCHROMATIN GENE REPRESSION INHIBITORS<br/>[FR] INHIBITEURS DE RÉPRESSION DE GÈNE D'HÉTÉROCHROMATINE
  申请人：UNIV NORTH CAROLINA CHAPEL HILL

  公开号：WO2019006322A1

  公开（公告）日：2019-01-03

  The present disclosure relates to chemical compounds that inhibit HP1-mediated heterochromatin formation, pharmaceutical compositions containing such compounds, methods of identifying such compounds, and their use in the treatment of disorders related to heterochromatin formation such as, for example, a disorder of cellular proliferation (e.g., cancer). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及抑制HP1介导的异染色质形成的化合物、含有这些化合物的药物组合物、识别这些化合物的方法，以及它们在治疗与异染色质形成相关的疾病中的用途，例如细胞增殖障碍（例如癌症）。本摘要旨在作为在特定领域搜索的扫描工具，不打算限制本发明。
• Heterochromatin gene repression inhibitors
  申请人：The University of North Carolina at Chapel Hill

  公开号：US11254654B2

  公开（公告）日：2022-02-22

  The present disclosure relates to chemical compounds that inhibit HP1-mediated heterochromatin formation, pharmaceutical compositions containing such compounds, methods of identifying such compounds, and their use in the treatment of disorders related to heterochromatin formation such as, for example, a disorder of cellular proliferation (e.g., cancer). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及抑制HP1介导的异染色质形成的化学化合物、含有此类化合物的药物组合物、鉴定此类化合物的方法，以及它们在治疗与异染色质形成有关的疾病（例如细胞增殖障碍（如癌症））中的用途。本摘要旨在作为在特定技术领域进行搜索的扫描工具，并非对本发明的限制。
• HETEROCHROMATIN GENE REPRESSION INHIBITORS
  申请人：The University of North Carolina at Chapel Hill

  公开号：EP3645006A1

  公开（公告）日：2020-05-06