Aminotris(dimethylamino)phosphonium hydrochloride | 14406-30-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Aminotris(dimethylamino)phosphonium hydrochloride
• 英文别名: amino-tris(dimethylamino)phosphonium chloride；aminotris(dimethylamino)phosphonium chloride；amino-tris(dimethylamino)phosphanium;chloride
• CAS: 14406-30-5
• 化学式: C₆H₂₀N₄P*Cl
• 分子量: 214.678
• InChiKey: WPVJGVLEONYYJY-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.69
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Aminotris(dimethylamino)phosphonium hydrochloride 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 1.0h， 以93%的产率得到亚氨基-三(二甲氨基)正膦
  参考文献：
  名称：

  PHOSPHAZENE COMPOUND, PREPARATION METHOD AND USE THEREOF

  摘要：

  提供了一种磷氮化合物，一种制备磷氮化合物的方法以及一种以磷氮化合物为催化剂生产聚合物的方法。该化合物的结构式（I）或其溶剂化合物，其中A是由重复的P═N组成的六元或八元环，B至少是未取代或取代的C1-6烷基氨基、未取代或取代的C1-6环烷基氨基、未取代或取代的芳基氨基或卤素中的至少一种，并且B连接到A上的磷处于P═N中，其中R是未取代或取代的C1-6烷基、未取代或取代的C1-6环烷基、未取代或取代的芳基或未取代或取代的苄基，或者R与N结合形成C1-6杂环烷基。

  公开号：

  US20190315786A1
• 作为产物：
  描述：

  二甲胺 在 五氯化磷 、 氨 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 Aminotris(dimethylamino)phosphonium hydrochloride
  参考文献：
  名称：

  PHOSPHAZENE COMPOUND, PREPARATION METHOD AND USE THEREOF

  摘要：

  提供了一种磷氮化合物，一种制备磷氮化合物的方法以及一种以磷氮化合物为催化剂生产聚合物的方法。该化合物的结构式（I）或其溶剂化合物，其中A是由重复的P═N组成的六元或八元环，B至少是未取代或取代的C1-6烷基氨基、未取代或取代的C1-6环烷基氨基、未取代或取代的芳基氨基或卤素中的至少一种，并且B连接到A上的磷处于P═N中，其中R是未取代或取代的C1-6烷基、未取代或取代的C1-6环烷基、未取代或取代的芳基或未取代或取代的苄基，或者R与N结合形成C1-6杂环烷基。

  公开号：

  US20190315786A1

文献信息

• Process for preparing phosphine oxides and process for purifying the same
  申请人：——

  公开号：US20020016504A1

  公开（公告）日：2002-02-07

  To provide a process for preparing phosphine oxides comprising reacting iminophosphoranes with phosphorus oxytrichloride by which highly purified phosphine oxides can be obtained industrially in a higher yield. Specifically, phosphine oxides are prepared in such a manner that iminophosphoranes are reacted with phosphorus oxytrichloride using an aprotic organic solvent with permittivity 2.2 or more at 20° C. as a solvent under special reaction conditions to give a liquid reaction product containing phosphine oxides and aminophosphonium chlorides which are yielded as a by-product at the same time as the phosphine oxides, and the above described chlorides are removed from the above described liquid reaction product by the solid-liquid separation process, and the solution having been subjected to the solid-liquid separation process is washed with water.

  提供一种制备膦氧化物的方法，包括通过将亚胺膦与三氯氧磷反应来制备膦氧化物，从而可以在较高的收率下工业上获得高度纯化的膦氧化物。具体地，通过在特殊反应条件下，使用介电常数在20°C时为2.2或更高的无极性有机溶剂作为溶剂，将亚胺膦与三氯氧磷反应，以得到含有膦氧化物和同时产生的氨基膦铵氯化物的液体反应产物，然后通过固液分离过程去除上述所述的氯化物，最后用水洗涤经过固液分离处理的溶液。
• Preparation process of iminotris ( Dimethylamino) phosphorane
  申请人：Mitsui Chemicals, Inc.

  公开号：US06090980A1

  公开（公告）日：2000-07-18

  A process is provided for preparing iminotris(dimethylamino)phosphorane at high purity and high yield from aminotris(dimethylamino)phosphonium chloride. Aminotris(dimethylamino)phosphonium chloride is first reacted with an aqueous solution of the hydroxide of an alkali metal or alkaline earth metal in the presence of a solvent in which the chloride and hydroxide of the alkali metal or alkaline earth metal are sparingly soluble, whereby iminotris(dimethylamino)phosphorane is formed. After water is dissolved off at a temperature of 70.degree. C. or lower from the reaction mixture, solids are removed from the thus-concentrated reaction mixture by solid-liquid separation. The resultant mother liquor is then distilled to obtain iminotris(dimethylamino)phosphorane.

  本发明提供了一种从氨基三(二甲氨基)磷酸铵制备高纯度和高收率的三(二甲氨基)膦酰胺的方法。首先，在碱金属或碱土金属的氢氧化物的水溶液中，在氯化碱金属或碱土金属和氢氧化物中难溶的溶剂存在下，将氨基三(二甲氨基)磷酸铵与之反应，形成三(二甲氨基)膦酰胺。在反应混合物中的水在70℃或更低温度下溶解后，通过固液分离从浓缩的反应混合物中去除固体。然后，将所得的母液蒸馏，以获得三(二甲氨基)膦酰胺。
• (Tris (dimethylamino) phosphonioamino) tris( tris (dimethylamino) phosphoranylideneamino) phosphonium dichloride and preparation process therefor
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP0924216A1

  公开（公告）日：1999-06-23

  A raw material is provided which permits preparation of tetrakis[tris(dimetHylamino)phosphoranylideneamino]phosphonium hydroxide by an extremely simple process. The raw material, [tris(dimethylamino)phosphonioamino]tris[tris(dimethylamino)phosphoranylidene amino]phosphonium dichloride is prepared by bringing hydrogen chloride into contact with tetrakis[tris(dimethylamino)phosphoranylideneamino]phosphonium chloride and adding the former on the latter. Tetrakis[tris(dimethylamino)phosphoranylideneamino]phosphonium hydroxide is prepared by bringing an aqueous solution of the dichoride into contact with an OH--form ion exchange resin. A separation process, is provided in which tetrakis[tris(dimethylamino)phosphoranylideneamino]phosphonium chloride is separated from solution by extracting it out, as [tris(dimethylamino)phosphonioamino]tris[tris(dimethylamino)phosphoranylidene amino]phosphonium dichloride, into a water phase. An isolation process is also provided, in which an aqueous solution of [tris(dimethylamino)phosphonioamino]tris[tris(dimethylamino)phosphoranylidene amino]phosphonium dichloride is neutralized so that tetrakis[tris(dimethylamino)phosphoranylideneamino]phosph onium chloride is regenerated and precipitated as a solid.

  本发明提供了一种原材料，可通过极其简单的工艺制备四[三(二甲氨基)亚磷酰氨基]氢氧化鏻。 原材料[三(二甲基氨基)磷酰氨基]三[三(二甲基氨基)磷酰亚氨基]二氯化鏻是通过氯化氢与四[三(二甲基氨基)磷酰亚氨基]氯化鏻接触并在后者上加入前者而制备的。四[三(二甲基氨基)磷酰亚氨基]氢氧化鏻是通过将二氯化碳水溶液与 OH 型离子交换树脂接触而制备的。 提供了一种分离工艺，将四[三(二甲基氨基)亚磷酰氨基]氯化鏻从溶液中分离出来，将其作为[三(二甲基氨基)亚磷酰氨基]三[三(二甲基氨基)亚磷酰氨基]二氯化鏻萃取到水相中。 还提供了一种分离工艺，在该工艺中，[三(二甲基氨基)膦酰氨基]三[三(二甲基氨基)磷酰亚氨基]二氯化鏻的水溶液被中和，从而使四[三(二甲基氨基)磷酰亚氨基]氯化鏻再生并沉淀为固体。
• A phosphine sulfide, a manufacturing process therefor and a use thereof
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP0972776A1

  公开（公告）日：2000-01-19

  A basic organic compound which is soluble in an organic solvent, does not have problems in its preparation or handling and exhibits catalytic activity as a basic compound, is a phosphine sulfide represented by the (1): The phosphine sulfide represented by formula (1), is made by reacting one molecule of thiophosphoryl chloride with three molecules of a phosphorane represented by formula (2): A process for effectively manufacturing a poly(alkylene oxide) involves polymerizing an alkylene oxide in the presence of the above organic compound (phosphine sulfide), or in the presence of the phosphine sulfide and an active hydrogen compound selected from water and organic compounds having a partial structure of -OH or -NH-. A process for manufacturing a 1,2-dioxyethane derivative from an epoxy compound, i.e. manufacturing a 1,2-dioxyethane derivative involves reacting an epoxy compound with a carboxylate, carboxylic anhydride, carbonate or phenol compound, respectively, in the presence of the phosphine sulfide.

  一种可溶于有机溶剂、在制备或处理过程中不会出现问题并具有催化活性的碱性有机化合物是硫化膦，其代表式为（1）： 式（1）代表的硫化膦是由一分子硫代磷酰氯与三分子式（2）代表的磷烷反应制得的： 一种有效制造聚环氧亚烷烃的工艺是在上述有机化合物（硫化膦）存在下，或在硫化膦和选 自水和部分结构为-OH 或-NH-的有机化合物的活性氢化合物存在下，聚合环氧亚烷烃。 由环氧化合物制造 1，2-二氧乙烷衍生物的工艺，即制造 1，2-二氧乙烷衍生物的工艺包括在硫化膦存在下，环氧化合物分别与羧酸盐、羧酸酐、碳酸盐或苯酚化合物反应。
• Process for purifying phosphine oxides
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP1241173A2

  公开（公告）日：2002-09-18

  The invention provides for purifying phosphine oxides which may be prepared in such a manner that iminophosphoranes are reacted with phosphorus oxytrichloride using an aprotic organic solvent with permittivity 2.2 or more at 20°C as a solvent under specical reaction conditions to give a liquid reaction product containing phosphine oxides and aminophosphonium chlorides which are yielded as a by-product at the same time as the phosphine oxides. The above described chlorides are removed from the above described liquid reaction product by the solid-liquid separation process, and the solution having been subjected to the solid-liquid separation process is washed with water.

  本发明提供了提纯氧化膦的方法，氧化膦的制备过程如下：亚氨基磷烷与三氯氧磷在20°C时以介电常数为2.2或更高的烷基有机溶剂作为溶剂，在特定的反应条件下进行反应，得到含有氧化膦和氨基鏻氯化物的液体反应产物，氨基鏻氯化物与氧化膦同时作为副产物生成。通过固液分离工艺从上述液体反应产物中除去上述氯化物，并用水洗涤经过固液分离工艺的溶液。