(6R,7S)-6,7-Dimethoxy-5,6,7,8-tetrahydro-naphthalen-1-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: (6R,7S)-6,7-Dimethoxy-5,6,7,8-tetrahydro-naphthalen-1-ol
• 英文别名: (6R,7S)-6,7-dimethoxy-5,6,7,8-tetrahydronaphthalen-1-ol
• 化学式: C₁₂H₁₆O₃
• 分子量: 208.257
• InChiKey: GRXRRYBLKOWSCW-NEPJUHHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (2R,3S)-5-Benzyloxy-1,2,3,4-tetrahydro-naphthalene-2,3-diol 、 碘甲烷 生成 (6R,7S)-6,7-Dimethoxy-5,6,7,8-tetrahydro-naphthalen-1-ol
  参考文献：
  名称：

  Nondepressant .beta.-adrenergic blocking agents. 1. Substituted 3-amino-1-(5,6,7,8-tetrahydro-1-naphthoxy)-2-propanols

  摘要：

  A series of 3-amino-1-(5,6,7,8-tetrahydronaphthoxy)-2-propanols was synthesized and investigated for beta-adrenergic blocking activity and direct myocardial depressant action. The cis- and trans-diols 12--15 were found to retain the beta-blocking potency of propranolol but to lack its myocardial depressant action. Compound 15 (nadolol) is currently undergoing extensive clinical evaluation as a potential antianginal, antiarrhythmic, and antihypertensive agent.

  DOI：

  10.1021/jm00207a014

文献信息

• Nondepressant .beta.-adrenergic blocking agents. 1. Substituted 3-amino-1-(5,6,7,8-tetrahydro-1-naphthoxy)-2-propanols
  作者：Michael E. Condon、Christopher M. Cimarusti、Rita Fox、V. L. Narayanan、Joyce Reid、Joseph E. Sundeen、Fred P. Hauck

  DOI：10.1021/jm00207a014

  日期：1978.9

  A series of 3-amino-1-(5,6,7,8-tetrahydronaphthoxy)-2-propanols was synthesized and investigated for beta-adrenergic blocking activity and direct myocardial depressant action. The cis- and trans-diols 12--15 were found to retain the beta-blocking potency of propranolol but to lack its myocardial depressant action. Compound 15 (nadolol) is currently undergoing extensive clinical evaluation as a potential antianginal, antiarrhythmic, and antihypertensive agent.