tyrosol pentanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: tyrosol pentanoate
• 英文别名: 2-(4-Hydroxyphenyl)ethyl pentanoate
• 化学式: C₁₃H₁₈O₃
• 分子量: 222.284
• InChiKey: PFGBJASSSCYMEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tyrosol pentanoate 在 Agaricus bisporus 、 氧气 作用下， 以 aq. phosphate buffer 、 二氯甲烷 为溶剂， 反应 24.0h， 以74%的产率得到hydroxytyrosol pentanoate
  参考文献：
  名称：

  Tyrosinase and Layer-by-Layer supported tyrosinases in the synthesis of lipophilic catechols with antiinfluenza activity

  摘要：

  Catechol derivatives with lipophilic properties have been selectively synthesized by tyrosinase in high yield avoiding long and tedious protection/deprotection steps usually required in traditional procedures. The synthesis was effective also with immobilized tyrosinase able to perform for more runs. The novel catechols were evaluated against influenza A virus, that continue to represent a severe threat worldwide. A significant antiviral activity was observed in derivatives characterized by antioxidant activity and long carbon alkyl side-chains, suggesting the possibility of a new inhibition mechanism based on both redox and lipophilic properties. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.10.026
• 作为产物：
  描述：

  对羟基苯乙醇 、 正戊酸 在 Candida antarctica 作用下， 反应 24.0h， 以100%的产率得到tyrosol pentanoate
  参考文献：
  名称：

  Tyrosinase and Layer-by-Layer supported tyrosinases in the synthesis of lipophilic catechols with antiinfluenza activity

  摘要：

  Catechol derivatives with lipophilic properties have been selectively synthesized by tyrosinase in high yield avoiding long and tedious protection/deprotection steps usually required in traditional procedures. The synthesis was effective also with immobilized tyrosinase able to perform for more runs. The novel catechols were evaluated against influenza A virus, that continue to represent a severe threat worldwide. A significant antiviral activity was observed in derivatives characterized by antioxidant activity and long carbon alkyl side-chains, suggesting the possibility of a new inhibition mechanism based on both redox and lipophilic properties. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.10.026

文献信息

• Optically active ester derivatives, preparation process thereof, liquid crystal materials and a light switching element
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0357372A2

  公开（公告）日：1990-03-07

  Disclosed are herein optically active ester derivatives represented by the formula (I): (wherein R1 represents an alkyl group having 3 to 20 carbon atoms; R2 represents an optically active alkyl or alkoxyalkyl group having 3 to 15 carbon atoms optionally substituted by halogen atoms; Y represents -O-, -COO- or -OCO-; X represents -COO- or -OCO-; represents a number of 1 or 2; k and m each represents a number of 0 or 1; n represents a numberof 1 to 6), preparation processes therefor, liquid crystal materials containing such easter derivatives as active ingredient, and a light switching element using said liquid crystal materials as liquid crystal element.

  本文公开了由式(I)代表的光学活性酯衍生物： (其中 R1 代表具有 3 至 20 个碳原子的烷基；R2 代表具有 3 至 15 个碳原子的光学活性烷基或烷氧基烷基，可选择被卤素原子取代；Y 代表 -O-、-COO- 或 -OCO-；X 代表 -COO- 或 -OCO-；代表 1 或 2 的数字；k 和 m 分别代表 0 或 1 的数字；n 代表 1 至 6 的数字）、其制备工艺、含有此类酯衍生物作为活性成分的液晶材料，以及使用上述液晶材料作为液晶元件的光开关元件。
• Carbon nanotubes supported tyrosinase in the synthesis of lipophilic hydroxytyrosol and dihydrocaffeoyl catechols with antiviral activity against DNA and RNA viruses
  作者：Giorgia Botta、Bruno Mattia Bizzarri、Adriana Garozzo、Rossella Timpanaro、Benedetta Bisignano、Donatella Amatore、Anna Teresa Palamara、Lucia Nencioni、Raffaele Saladino

  DOI：10.1016/j.bmc.2015.07.061

  日期：2015.9

  Hydroxytyrosol and dihydrocaffeoyl catechols with lipophilic properties have been synthesized in high yield using tyrosinase immobilized on multi-walled carbon nanotubes by the Layer-by-Layer technique. All synthesized catechols were evaluated against a large panel of DNA and RNA viruses, including Poliovirus type 1, Echovirus type 9, Herpes simplex virus type 1 (HSV-1), Herpes simplex virus type 2 (HSV-2), Coxsackievirus type B3 (Cox B3), Adenovirus type 2 and type 5 and Cytomegalovirus (CMV). A significant antiviral activity was observed in the inhibition of HSV-1, HSV-2, Cox B3 and CMV. The mechanism of action of the most active dihydrocaffeoyl derivative was investigated against a model of HSV-1 infection. (C) 2015 Elsevier Ltd. All rights reserved.
• US5053507A
  申请人：——

  公开号：US5053507A

  公开（公告）日：1991-10-01
• US5124070A
  申请人：——

  公开号：US5124070A

  公开（公告）日：1992-06-23
• US5264151A
  申请人：——

  公开号：US5264151A

  公开（公告）日：1993-11-23