4,5-dimethyl-5-phenylfuran-2(5H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 4,5-dimethyl-5-phenylfuran-2(5H)-one
• 英文别名: 4,5-dimethyl-5-phenylfuran-2-one
• 化学式: C₁₂H₁₂O₂
• 分子量: 188.226
• InChiKey: XSOBZPVWUACBKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-methyl-3-phenylbut-1-en-3-ol 以68%的产率得到
  参考文献：
  名称：

  Kondo Teruyuki, Kodoi Kouichi, Mitsudo Take-aki, Watanabe Yoshihisa, J. Chem. Soc. Chem. Commun, (1994) N 6, S 755-756

  摘要：

  DOI：

文献信息

• Stereoselective preparation of highly functionalized (Z)-3-magnesiated enoates by an iodine–magnesium exchange reaction
  作者：Ioannis Sapountzis、Wolfgang Dohle、Paul Knochel

  DOI：10.1039/b106195j

  日期：2001.10.11

  3-Iodoenoates are converted into the corresponding alkenylmagnesium species with complete retention of configuration of the double bond; both direct reaction and copper(I)-mediated reactions with various electrophiles provide polyfunctional enoates.

  3-碘烯酸酯可以转化为相应的烯基镁物种，双键的构型完全保留；直接反应和铜(I)介导的与各种电亲核试剂的反应都能提供多功能的烯酸酯。
• Synthesis of heterospirans containing a γ-lactone ring
  作者：A. A. Avetisyan、G. G. Tokmadzhyan、R. A. Piridzhanyan

  DOI：10.1134/s1070428008070221

  日期：2008.7

  Reactions of alpha-ketols with diethyl malonate at the molar ratio 2:1 in the presence of K(2)CO(3) were investigated. The heterospiranes obtained contained a dihydrofuran and a gamma-lactone rings. The optimum conditions for the synthesis of heterospiranes were found by varying the ratio of the initial compounds: alpha-ketoalcohol (or 2-ethoxycarbonyl-, 2-methoxycarbonyl-, 2-cyano-3,4,4-trimethyl-2-buten-4-olides), diethyl malonate, K(2)CO(3), by varying the environment, and also the temperature and the time of the reaction.
• INOUE, YOSHIO;HIBI, TAKUO;SATAKE, MASAKI;KAWASHIMA, YASUHIKO;HASHIMOTO, H+, J. CHEM. SOC. JAP., CHEM. AND IND. CHEM., 1982, N 2, 276-281
  作者：INOUE, YOSHIO、HIBI, TAKUO、SATAKE, MASAKI、KAWASHIMA, YASUHIKO、HASHIMOTO, H+

  DOI：——

  日期：——