ethyl 2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylate hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: ethyl 2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylate hydrochloride
• 英文别名: Ethyl 2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylate, hydrochloride salt；ethyl 2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylate;hydrochloride
• 化学式: C₁₁H₁₃ClN₂O₂*ClH
• 分子量: 277.15
• InChiKey: JULIISKYJRHADU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.98
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  51.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  异丙醚 、 1-氯乙基氯甲酸酯 以 二氯甲烷 为溶剂， 生成 ethyl 2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylate hydrochloride
  参考文献：
  名称：

  3-oxadiazolyl-1,6-naphthyridine derivatives

  摘要：

  3-氧代唑基-5,6,7,8-四氢-1,6-萘啶衍生物的化学式（I）：##STR1## 其中Het是氧代唑环，R.sub.1是氢原子，酰基，较低的烷基基团或化学式的基团：--CH.sub.2 R.sub.1'（其中R.sub.1'是环状较低烷基基团，较低烯基基团，较低炔基团，苄基团，芳基或杂芳基团），R.sub.2是较低的烷基基团，环状较低烷基基团，较低烯基基团，较低炔基团，芳基，杂芳基，卤代较低烷基基团，较低烷氧基较低烷基基团，较低烷氧基团，较低烯氧基团，苯氧基团或较低烷硫基团，或其药学上可接受的酸盐，可用作苯二氮卓啉受体激动剂。

  公开号：

  US05367078A1

文献信息

• 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
  申请人：Ashton T Wallace

  公开号：US20060074087A1

  公开（公告）日：2006-04-06

  The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及3-氨基-4-苯基丁酸衍生物，它们是二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂，可用于治疗或预防二肽基肽酶-IV酶涉及的疾病，如糖尿病，特别是2型糖尿病。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗二肽基肽酶-IV酶涉及的这些疾病中使用这些化合物和组合物。
• 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
  申请人：Merck & Co., Inc.

  公开号：US07388019B2

  公开（公告）日：2008-06-17

  The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及3-氨基-4-苯基丁酸衍生物，其是二肽基肽酶IV酶（“DP-IV抑制剂”）的抑制剂，对于涉及二肽基肽酶IV酶的疾病，如糖尿病，尤其是2型糖尿病的治疗或预防有用。本发明还涉及包含这些化合物的制药组合物以及在涉及二肽基肽酶IV酶的这些疾病的预防或治疗中使用这些化合物和组合物。
• 3-Oxadiazolyl-1,6-naphthyridine derivatives with affinity for benzodiazepine receptors
  申请人：DAINIPPON PHARMACEUTICAL CO., LTD.

  公开号：EP0588500A2

  公开（公告）日：1994-03-23

  A 3-Oxadiazolyl-5,6,7,8-tetrahydro-1,6-naphthyridine derivative of the formula (I) : wherein Het is an oxadiazole ring, R1 is hydrogen atom, an acyl group, a lower alkyl group or a group of the formula: -CH2R1' (in which R1' is a cyclo-lower alkyl group, a lower alkenyl group, a lower alkynyl group, benzyl group, aryl group or a heteroaromatic group), R2 is a lower alkyl group, a cyclo-lower alkyl group, a lower alkenyl group, a lower alkynyl group, aryl group, a heteroaromatic group, a halogeno-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkoxy group, a lower alkenyloxy group, a phenoxy group or a lower alkylthio group, or a pharmaceutically acceptable acid addition salt thereof, is useful as benzodiazepine receptor agonist.

  一种式 (I) 的 3-噁二唑基-5,6,7,8-四氢-1,6-萘啶衍生物： 其中 Het 是一个噁二唑环，R1 是氢原子、酰基、低级烷基或式中的一个基团：-R2是低级烷基、环低级烷基、低级烯基、低级炔基、苄基、芳基或杂芳基；R3是低级烷基、环低级烷基、低级烯基、低级炔基、芳基、杂芳基或杂芳基；R4是低级烷基、环低级烷基、低级烯基、低级炔基、芳基、杂芳基或杂芳基；R5是低级烷基、环低级烷基、低级烯基、低级炔基、芳基、杂芳基或杂芳基、卤素-低级烷基、低级烷氧基-低级烷基、低级烷氧基、低级烯氧基、苯氧基或低级烷硫基，或其药学上可接受的酸加成盐，可用作苯并二氮杂卓受体激动剂。
• NOVEL NAPHTHYRIDINE DERIVATIVES OR SALTS THEREOF
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：EP0997462A1

  公开（公告）日：2000-05-03

  A novel naphthyridine compound represented by the general formula (1): wherein R1, R2 and R3 are independently a hydrogen atom, a lower alkyl group or the like, or R1 and R2, or R2 and R3, when taken together, form a cyclic group; each of X and Y is a methylene or ethylene group; Z is a phenyl group, a substituted phenyl group or the like; A is a hydrogen atom, a lower alkyl group or the like; and G is an acyl group, shows antagonism for tachykinin receptors and is useful as a prophylactic or therapeutic agent for diseases for which the tachykinin receptors are considered to be responsible. A specific example of such a compound is 2-[(-)-4-(N-benzoyl-N-methyl)amino-3-(3,4-dichlorophenyl)butyl]-10-acetylamino-1,2,3,4-tetrahydro-benzo[b][1,6]naphthyridine.

  一种通式（1）代表的新型萘啶化合物： 其中 R1、R2 和 R3 独立地为氢原子、低级烷基或类似基团，或 R1 和 R2 或 R2 和 R3 合在一起形成环状基团；X 和 Y 各为亚甲基或亚乙基；Z 为苯基、取代苯基或类似基团；A 是氢原子、低级烷基或类似基团；G 是酰基，显示出对速激肽受体的拮抗作用，可用作速激肽受体被认为是致病原因的疾病的预防或治疗剂。这种化合物的一个具体例子是 2-[(-)-4-(N-苯甲酰基-N-甲基)氨基-3-(3,4-二氯苯基)丁基]-10-乙酰氨基-1,2,3,4-四氢苯并[b][1,6]萘啶。
• US5367078A
  申请人：——

  公开号：US5367078A

  公开（公告）日：1994-11-22