亚甲基去氢乙酰氧基黄体酮 | 805-84-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 亚甲基去氢乙酰氧基黄体酮
• 中文别名: 5-[(4-羟基苯基)偶氮]-8-[[4-[(4-硝基-2-磺酸根苯基)氨基]苯基]偶氮]萘-2-磺化二钠
• 英文名称: Superlutin
• 英文别名: [(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-16-methylidene-3-oxo-1,2,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-yl] acetate
• CAS: 805-84-5
• 化学式: C₂₄H₃₀O₄
• 分子量: 382.5
• InChiKey: UXRDAJMOOGEIAQ-CKOZHMEPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Novel C18 modified retrosteroids as progesterone receptor modulator compounds
  申请人：Messinger Joseph

  公开号：US20070082876A1

  公开（公告）日：2007-04-12

  Retrosteroidal compounds of formula I which act as progesterone receptor modulators, a method for their production, and pharmaceutical preparations containing these compounds. These compounds are preferably used for the treatment of benign gynecological disorders such as endometriosis and uterine fibroids, as well as for female birth control and for hormone replacement therapy (HRT).

  公式I的复古类固醇化合物，其作为孕激素受体调节剂的方法，以及含有这些化合物的药物制剂。这些化合物通常用于治疗良性妇科疾病，如子宫内膜异位症和子宫肌瘤，以及用于女性避孕和激素替代疗法（HRT）。
• C11 Modified Retrosteroids as Progesterone Receptor Modulator Compounds
  申请人：Messinger Josef

  公开号：US20080249075A1

  公开（公告）日：2008-10-09

  Retrosteroidal compounds corresponding to formula I, representing progesterone receptor modulators, and their production, and pharmaceutical preparations containing these compounds. These compounds are useful in the treatment of benign gynecological disorders such as endometriosis and uterine fibroids, as well as for female birth control and for hormone replacement therapy.

  与公式I对应的复古类固醇化合物，代表孕激素受体调节剂，以及它们的生产和含有这些化合物的药物制剂。这些化合物在治疗良性妇科疾病，如子宫内膜异位症和子宫肌瘤，以及用于女性避孕和激素替代疗法方面非常有用。
• Microbial method for the 11beta hydroxylation of 9beta, 10alpha-steriods
  申请人：Messinger Josef

  公开号：US20070212751A1

  公开（公告）日：2007-09-13

  Use of bacterial strains of the species Amycolatopsis mediterranei for microbial transformation of 9β,10α-steroids of formula (I) to their corresponding 11β-hydroxyl analogues, as well as specific strains of that species, a process for transforming 9β,10α-steroids to their corresponding 11β-hydroxyl derivatives using bacterials strains of the species Amycolatopsis mediterranei , and subsequent isolation of the 11β-hydroxyl derivatives from the bacterial culture medium. The resulting 11β-hydroxylated products are useful intermediates for preparing novel steroidal compounds with 9β,10α-confirmation carrying different kinds of substituents in the 11β-position.

  使用地中海链霉菌(Amycolatopsis mediterranei)的细菌菌株对式(I)的9β,10α类固醇进行微生物转化，以得到相应的11β-羟基类似物，该物种的特定菌株，以及使用地中海链霉菌的细菌菌株将9β,10α类固醇转化为相应的11β-羟基衍生物的过程，并从细菌培养基中分离11β-羟基衍生物。由此产生的11β-羟基化产物是制备具有不同11β位置取代基的9β,10α-确认的新型类固醇化合物的有用中间体。
• NOVEL C18 MODIFIED RETROSTEROIDS AS PROGESTERONE RECEPTOR MODULATOR COMPOUNDS
  申请人：Solvay Pharmaceuticals GmbH

  公开号：EP1928894A1

  公开（公告）日：2008-06-11
• PROCESS FOR THE PREPARATION OF 11BETA-HYDR0XY-9BETA, 10ALPHA -STEROIDS EMPLOYING AMYCOLATOPSIS MEDITERRANEI CELLS
  申请人：Solvay Pharmaceuticals GmbH

  公开号：EP1976997A1

  公开（公告）日：2008-10-08