N,N,N',N',-Tetrakis(2,3-dihydroxypropyl) ethylenediamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N,N',N',-Tetrakis(2,3-dihydroxypropyl) ethylenediamine
• 英文别名: N,N,N',N'-Tetrakis(2,3-dihydroxypropyl)-ethylenediamine；N,N,N',N'-tetrakis(2,3-dihydroxypropyl)ethylenediamine；3-[2-[Bis(2,3-dihydroxypropyl)amino]ethyl-(2,3-dihydroxypropyl)amino]propane-1,2-diol
• 化学式: C₁₄H₃₂N₂O₈
• 分子量: 356.417
• InChiKey: NHVSPPAWKASEPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.9
• 重原子数：
  24
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  168
• 氢给体数：
  8
• 氢受体数：
  10

文献信息

• Neuroprotection and cardioprotection afforded by chelators with high affinity and specificity for cations of first transition series elements
  申请人：CONCAT, LTD. a California Limited Partnership

  公开号：US20040006055A1

  公开（公告）日：2004-01-08

  Compounds that demonstrate chelation affinity and selectivity for first transition series elements are administered to patients suffering from such conditions as ischemia, prolonged seizures and trauma to provide neuroprotection, cardioprotection, or both. These compounds when administered form complexes with chelatable iron and copper cations and thereby mitigate the ability of these cations to catalyze Haber-Weiss reactions that form toxic hydroxy free radicals that cause tissue injury. These compounds also form complexes with chelatable zinc cations thereby inhibiting the cytotoxicity associated with excess chelatable zinc.

  表现出对第一过渡系列元素具有螯合亲和力和选择性的化合物被用于治疗患有缺血、持续性癫痫和创伤等疾病的患者，以提供神经保护、心脏保护或两者兼而有之。这些化合物在被给药时会与可螯合的铁和铜阳离子形成络合物，从而减轻这些阳离子催化哈伯-魏斯反应的能力，这些反应会产生导致组织损伤的有毒羟自由基。这些化合物还会与可螯合的锌阳离子形成络合物，从而抑制与过多可螯合锌相关的细胞毒性。
• Compounds with chelation affinity and selectivity for first transition series elements and their use in cosmetics and personal care products, inhibition of metalloenzymes, and inhibition of reperfusion injury
  申请人：——

  公开号：US20010041170A1

  公开（公告）日：2001-11-15

  This invention involves the use of a class of compounds with chelation affinity and selectivity for first transition series elements. Application or administration of the free or conjugated compound, or physiological salts of the free or conjugated compound, results in decrease of the bioavailability and/or chemical action of first transition series elements. These characteristics make such compounds useful in cosmetics and personal care products to decrease odor arising from microbial growth on body surfaces and in body cavities, decrease microbial growth on teeth, plaque, and gums that cause tooth decay and gum disease, inhibition of oxidative damage to the skin, inhibition of enzymatic action of metalloenzymes dependent on first transition series elements, and inhibition of reperfusion injury.

  这项发明涉及使用一类对第一过渡系列元素具有螯合亲和力和选择性的化合物。应用或给予自由或结合化合物，或自由或结合化合物的生理盐，可导致第一过渡系列元素的生物利用度和/或化学作用降低。这些特性使得这些化合物在化妆品和个人护理产品中非常有用，可减少身体表面和身体腔内微生物生长引起的气味，减少导致牙齿蛀牙和牙龈疾病的牙菌斑和牙龈微生物生长，抑制皮肤氧化损伤，抑制依赖于第一过渡系列元素的金属酶的酶促作用，以及抑制再灌注损伤。
• Macrophage stimulation by homolog or analog of quadrol
  申请人：The University of Akron

  公开号：EP0372123A1

  公开（公告）日：1990-06-13

  Quadrol and homologs and analogs thereof have been found to stimulate macrophage activity in warm blooded animals. As a consequence, these compounds may be used to combat bacterial infection, remove degenerated tissue, and promote new tissue growth. Quadrol or a homolog or analog thereof may be applied topically, e.g., as the active agent in a wound dressing. The active compounds may be represented by the formula (I) wherein R₁ and R₂ are substituted alkyl (C₂-­C₆) in which the substituents include one or more hydroxyl groups attached to carbon atoms other than the alpha carbon atom, R₃ and R₄ are alkyl or substituted alkyl (C₁-C₆), and n=2 to about 6. Preferably R₁ through R₄ are the same and are 2-hydroxyalkyl.

  研究发现，Quadrol 及其同源物和类似物可刺激温血动物体内巨噬细胞的活性。因此，这些化合物可用于对抗细菌感染、清除退化组织和促进新组织生长。Quadrol 或其同源物或类似物可局部使用，例如作为伤口敷料中的活性剂。活性化合物可由式 (I) 表示 其中 R₁ 和 R₂ 是取代的烷基 (C₂-C₆)，其中取代基包括一个或多个连接到除α 碳原子以外的碳原子上的羟基，R₃ 和 R₄ 是烷基或取代的烷基 (C₁-C₆)，且 n=2 至约 6。R₁ 至 R₄ 最好是相同的 2-羟基烷基。
• Method for inhibiting bacterial or fungal growth using a polyamine derivative as complexing agent
  申请人：Chelator LLC

  公开号：EP1382332A1

  公开（公告）日：2004-01-21

  The present invention refers to a method for inhibiting bacterial or fungal growth on a surface, including a human body surface, or in a solution comprising administering to said surface or solution a complexing agent having the formula wherein said radicals and integers are defined as in the description.

  本发明涉及一种抑制细菌或真菌在表面上（包括人体表面）或溶液中生长的方法，该方法包括在所述表面或溶液中施用一种具有以下式子的络合剂 其中，所述基团和整数的定义与描述相同。
• Compositions containing N,N,N',N'-tetrakis(hydroxyalkyl)diamine-or N,N,N',N'-tetrakis(hydroxyalkoxy)diamine-based buffers
  申请人：Salamone C. Joseph

  公开号：US20060047005A1

  公开（公告）日：2006-03-02

  The use of compositions containing one or more antimicrobial agents with one or more (hydroxyalkyl)diamine-based buffers, (hydroxyalkoxy)diamine-based buffers or combinations thereof to disinfect and/or preserve medical devices is described. Solutions containing one or more antimicrobial agents with one or more (hydroxyalkyl)diamine-based buffers, (hydroxyalkoxy)diamine-based buffers or combinations thereof and methods of making and using the same are also described.

  描述了含有一种或多种抗菌剂与一种或多种(羟烷基)二胺基缓冲剂、(羟烷氧基)二胺基缓冲剂或其组合的组合物在消毒和/或保存医疗器械方面的用途。还描述了含有一种或多种抗菌剂与一种或多种(羟烷基)二胺基缓冲剂、(羟烷氧基)二胺基缓冲剂或其组合的溶液，以及制造和使用这些溶液的方法。