2-methyl-5,6,7,8-tetrahydroisoquinolin-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2-methyl-5,6,7,8-tetrahydroisoquinolin-1-one
• 英文别名: 2-methyl-5,6,7,8-tetrahydroisoquinolin-1(2H)-one
• 化学式: C₁₀H₁₃NO
• 分子量: 163.219
• InChiKey: BXALXCYJIJIYSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (1R,8S)-9-methyl-9-azatricyclo[6.2.2.01,6]dodec-6-en-10-one 生成 2-methyl-5,6,7,8-tetrahydroisoquinolin-1-one
  参考文献：
  名称：

  KUNG T. C.; GUTSCHE C. D., J. ORG. CHEM., 1978, 43, NO 21, 4069-4075

  摘要：

  DOI：

文献信息

• BROMODOMAIN INHIBITORS
  申请人：Quanticel Pharmaceuticals

  公开号：US20150111885A1

  公开（公告）日：2015-04-23

  The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.

  本发明涉及替代杂环衍生物化合物，包括所述化合物的组合物，以及通过抑制溴结构域介导的蛋白质乙酰赖氨酸区域的识别来进行表观遗传调控的所述化合物和组合物的用途。所述组合物和方法对于癌症和肿瘤性疾病的治疗是有用的。
• Co(III)-Catalyzed Annulative Vinylene Transfer via C–H Activation: Three-Step Total Synthesis of 8-Oxopseudopalmatine and Oxopalmatine
  作者：Xinghua Li、Ting Huang、Ying Song、Yue Qi、Limin Li、Yanping Li、Qi Xiao、Yuanfei Zhang

  DOI：10.1021/acs.orglett.0c02016

  日期：2020.8.7

  with vinylene carbonate for the synthesis of isoquinolinones and pyridinones has been developed. This protocol employing inexpensive Co(III) as the catalyst tolerated diverse functional groups and substitution patterns, affording the target products with good to excellent yields. The synthetic utility of this transformation was demonstrated by a three-step synthesis of gusanlung D, 8-oxopseudopalmatine

  已经开发了Co（III）催化苯甲酰胺和丙烯酰胺与碳酸亚乙烯酯的氧化还原中性环化反应，用于合成异喹啉酮和吡啶酮。该方案采用廉价的Co（III）作为催化剂，可耐受各种官能团和取代方式，从而为目标产物提供了良好或优异的收率。该转化的合成效用通过古桑隆D，8-氧代伪巴马汀和氧代巴马汀的三步合成得到证明。
• SUBSTITUTED TETRAHYDRO-2H-ISOQUINOLIN-1-ONE DERIVATIVES, AND METHODS FOR THE PRODUCTION AND USE THEREOF
  申请人：PEUKERT Stefan

  公开号：US20070142430A1

  公开（公告）日：2007-06-21

  This invention relates to compounds according to the general formula (I), where the definitions of the substituents R1, R2, Ar and X are as specified in the description, and to their physiologically tolerated salts, methods for the preparation of these compounds and their use as medicaments. These compounds are poly(ADP-ribose) polymerase (PARP) inhibitors.

  本发明涉及一般式（I）的化合物，其中取代基R1、R2、Ar和X的定义如说明书中所述，并且涉及这些化合物的生理耐受盐、制备这些化合物的方法以及它们作为药物的应用。这些化合物是聚(ADP-核糖)聚合酶(PARP)抑制剂。
• Bromodomain inhibitors
  申请人：Celgene Quanticel Research, Inc.

  公开号：US10023592B2

  公开（公告）日：2018-07-17

  The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.

  本发明涉及取代的杂环衍生物化合物、包含所述化合物的组合物，以及所述化合物和组合物通过抑制溴域介导的对组蛋白等蛋白质乙酰赖氨酸区的识别而用于表观遗传调控的用途。所述组合物和方法可用于治疗癌症和肿瘤性疾病。
• US7795278B2
  申请人：——

  公开号：US7795278B2

  公开（公告）日：2010-09-14