3-phenyl-2-phenylimino-5-vanillylidene-thiazolidin-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-phenyl-2-phenylimino-5-vanillylidene-thiazolidin-4-one
• 英文别名: 3-Phenyl-2-phenylimino-5-vanillyliden-thiazolidin-4-on
• 化学式: C₂₃H₁₈N₂O₃S
• 分子量: 402.474
• InChiKey: GIHVLLGPBSDCRL-YACCPEJUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.21
• 重原子数：
  29.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  62.13
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  1,1-二苯基硫脲 生成 3-phenyl-2-phenylimino-5-vanillylidene-thiazolidin-4-one
  参考文献：
  名称：

  Ahuja; Dutt, Journal of the Indian Chemical Society, 1951, vol. 28, p. 12

  摘要：

  DOI：

文献信息

• Thiazolidinones as cellular anandamide uptake inhibitors and their use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation
  申请人：UNIVERSITAT BERN

  公开号：US10300048B2

  公开（公告）日：2019-05-28

  The invention relates to a compound comprising the following general formula (1) for use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation: (1) wherein each of R1, R2 and R3 are selected independently from each other from alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, aryl, heterocycle or heteroaryl.

  本发明涉及一种包含以下通式（1）的化合物，用于治疗精神或神经系统疾病和炎症，特别是神经炎症：（1）其中 R1、R2 和 R3 各自独立地选自烷基、烷氧基、烯基、炔基、环烷基、芳基、杂环或杂芳基。
• THIAZOLIDINONES AS CELLULAR ANANDAMIDE UPTAKE INHIBITORS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION
  申请人：UNIVERSITÄT BERN

  公开号：US20170296515A1

  公开（公告）日：2017-10-19

  The invention relates to a compound comprising the following general formula (1) for use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation: (1) wherein each of R1, R2 and R3 are selected independently from each other from alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, aryl, heterocycle or heteroaryl.
• Ahuja; Dutt, Journal of the Indian Chemical Society, 1951, vol. 28, p. 12
  作者：Ahuja、Dutt

  DOI：——

  日期：——