全氟十三烷酸甲酯 | 185230-63-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 中文名称: 全氟十三烷酸甲酯
• 英文名称: Methyl perfluorotridecanoate
• 英文别名: methyl 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,13-pentacosafluorotridecanoate
• CAS: 185230-63-1
• 化学式: C₁₄H₃F₂₅O₂
• 分子量: 678.137
• InChiKey: MCVGSSHSKHYZGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  41
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  27

反应信息

• 作为反应物：
  描述：

  全氟十三烷酸甲酯 在 lithium aluminium tetrahydride 作用下， 生成
  参考文献：
  名称：

  疏水作用对光化学和光物理过程的影响：水性有机溶剂中全氟化碳聚集的证据

  摘要：

  氟化烷基-2-萘（NPFC的发射光谱和光二Ñ）和9-蒽甲基perfluoroalkanoates（AnFC Ñ在水-有机溶剂的二进制）进行了研究。NpFC n在二甲亚砜-水混合物（DMSO-H 2 O）中的荧光光谱受准分子发射支配。向溶液中加入长链碳氟化合物可减少受激准分子的发射并增加单体的发射。在NPFC的混合物溶液中的萘部分的有选择性的激励Ñ和AnFC Ñ从AnFC导致强发射Ñ。NpFC n的光辐照产生具有相对高量子产率的“类古巴”光电二聚体。所有这些观察结果表明，疏水相互作用迫使带有长碳氟化合物链的分子在水性有机二元溶剂中形成聚集体。

  DOI：

  10.1039/ft9959102761
• 作为产物：
  描述：

  甲醇 、 全氟十三酸 生成 全氟十三烷酸甲酯
  参考文献：
  名称：

  Aggregation Behavior of Mixed Fluorocarbon and Hydrocarbon Molecules in Aqueous Organic Solvents. Nonideality and Ideality of Mixing

  摘要：

  The emission spectra of naphthalene labeled hydrocarbons (NpHCn) and fluorocarbons (NpFCn) and anthracene labeled hydrocarbons (AnHCn) and fluorocarbons (AnFCn) in aqueous organic mixed solvents were investigated. The fluorescence spectrum of NpHC16 in dimethyl sulfoxide-water (DMSO-H2O) is dominated by excimer emission due to formation of aggregates. Addition of a fluorocarbon compound with chain length of seven perfluoromethylenes results in a reduction in the excimer emission and an enhancement of monomer emission, suggesting formation;of coaggregates. In contrast, addition of a perfluorocarbon compound with chain length of 12 perfluoromethylenes results in no change in the fluorescence spectrum of NpHC16. Similarly, NpFC7 and NpFC12 in DMSO-H2O also exhibit excimer emission exclusively. Fluorescence studies show that hydrocarbon compounds coaggregate with NpFC7 but do not coaggregate with NpFC12. Selective excitation of the naphthalene moiety in the mixture solution of NpHC16 with AnFC7 or in the mixture solution of NpFC7 with AnHC12 exclusively leads to the emission of the anthracene moiety, suggesting that efficient energy transfer between the naphthalene and the anthracene chromophores occurs. On the other hand, for the mixture of NpHC16 with AnFC12 or NpFC12 with AnHC12, no energy transfer was detected. All these observations indicate that fluorocarbon compounds with short chains can mix with hydrocarbon compounds ideally, while those with long chains behave nonideally. The mixed critical aggregation concentrations of NpHC16 with NpFC7 and with NpFC12 are measured as a function of overall composition of the mixtures, which give insight into the magnitude of the nonideality of the mixings.

  DOI：

  10.1021/j100020a065

文献信息

• COMPOSITIONS, METHODS, AND SYSTEMS COMPRISING FLUOROUS-SOLUBLE POLYMERS
  申请人：Swager Timothy M.

  公开号：US20120177578A1

  公开（公告）日：2012-07-12

  The present invention generally relates to compositions, methods, and systems comprising polymers that are fluorous-soluble and/or organize at interfaces between a fluorous phase and a non-fluorous phase. In some embodiments, emulsions or films are provided comprising a polymer. The polymers, emulsions, and films can be used in many applications, including for determining, treating, and/or imaging a condition and/or disease in a subject. The polymer may also be incorporated into various optoelectronic device such as photovoltaic cells, organic light-emitting diodes, organic field effect transistors, or the like. In some embodiments, the polymers comprise pi-conjugated backbones, and in some cases, are highly emissive.

  本发明通常涉及包含聚合物的组合物、方法和系统，该聚合物是可以在氟化物相和非氟化物相之间界面上溶解或组织的。在某些实施例中，提供了包含聚合物的乳液或薄膜。这些聚合物、乳液和薄膜可以用于许多应用，包括用于确定、治疗和/或成像受试者的状况和/或疾病。该聚合物也可以被纳入各种光电器件中，如光伏电池、有机发光二极管、有机场效应晶体管等。在某些实施例中，该聚合物包括π-共轭骨架，并且在某些情况下，具有高发光性。
• PHARMACEUTICAL COMPOSITIONS CONTAINING FLUORINATED OR PERFLUORINATED CARBOXYLIC ACIDS
  申请人：ELCOMBE CLIFFORD R.

  公开号：US20120029079A1

  公开（公告）日：2012-02-02

  The molecules of formula (I) are useful in treating diabetes, obesity, hypercholesterolaemia, hyperlipidaemia, cancer, inflammation or other conditions in which modulation of lipis of eicosanoid status or functions may be desirable. Formula (I): Z 1 —Z 1 —Z 2 wherein a) Z 1 represents CO 2 H or a derivative thereof; b) Z 2 represents F, H, —CO 2 H or a derivative thereof; and c) X represents fluorinated alkylene; or a solvate thereof, for example a perfluorinated fatty acid or derivative thereof.

  式(I)的分子在治疗糖尿病、肥胖症、高胆固醇血症、高脂血症、癌症、炎症或其他需要调节脂质或前列腺素状态或功能的情况中是有用的。式(I)：Z1—Z1—Z2其中a) Z1表示CO2H或其衍生物；b) Z2表示F、H、—CO2H或其衍生物；c) X表示氟化烷基；或其溶剂化物，例如全氟脂肪酸或其衍生物。
• Uses of perfluorinated carboylic acid derivatives for the manufacture of a medicament for the modulation of body mass
  申请人：CXR BIOSCIENCES LIMITED

  公开号：EP1745779A2

  公开（公告）日：2007-01-24

  The molecules of formula I are useful in treating diabetes, obesity, hypercholesterolaemia, hyperlipidaemia, cancer, inflammation or other conditions in which modulation of lipid or eicosanoid status or function may be desirable. Formula I:          Z1-X-Z2     I wherein Z1 represents -CO2H or a derivative thereof; Z2 represents F, H, -CO2H or a derivative thereof; and X represents fluorinated alkylene; or a solvate thereof, for example a perfluorinated fatty acid or derivative thereof.

  式 I 分子可用于治疗糖尿病、肥胖症、高胆固醇血症、高脂血症、癌症、炎症或其他需要调节脂质或类二十烷状态或功能的疾病。 式 I： Z1-X-Z2 I 其中 Z1 代表 -CO2H 或其衍生物； Z2 代表 F、H、-CO2H 或其衍生物；以及 X 代表氟化亚烷基； 或其溶解物、 例如全氟脂肪酸或其衍生物。
• Novel aerosol formulation containing a polar fluorinated molecule
  申请人：——

  公开号：US20030194378A1

  公开（公告）日：2003-10-16

  The present invention relates to a stable pharmaceutical aerosol formulation intended for inhalation. The formulation contains an active substance, an aerosol propellant, a polar flurorinated molecule and an excipient. The preferred propellant is HFA 134a or HFA 227 or a mixture thereof.

  本发明涉及一种用于吸入的稳定药用气溶胶制剂。该制剂含有一种活性物质、一种气溶胶推进剂、一种极性氟化分子和一种赋形剂。优选的推进剂是 HFA 134a 或 HFA 227 或它们的混合物。
• Methods
  申请人：Elcombe R. Clifford

  公开号：US20050175639A1

  公开（公告）日：2005-08-11

  The molecules of formula (I) are useful in treating diabetes, obesity, hypercholesterolaemia, hyperlipidaemia, cancer, inflammation or other conditions in which modulation of lipid or eicosanoid status or functions may be desirable. Formula (I): Z 1 -X-Z 2 wherein a) Z 1 represents CO 2 H or a derivative thereof; b) Z 2 represents F, H, —CO 2 H or a derivative thereof; and c) X represents fluorinated alkylene; or a solvate thereof, for example a perfluorinated fatty acid or derivative thereof.

  式（I）分子可用于治疗糖尿病、肥胖症、高胆固醇血症、高脂血症、癌症、炎症或其他需要调节脂质或类二十烷状态或功能的疾病。式 (I)：Z 1 -X-Z 2 其中 a) Z 1 代表 CO 2 H 或其衍生物； b) Z 2 代表 F、H、-CO 2 H 或其衍生物；以及 c) X 代表氟化亚烷基；或其溶解物，例如全氟脂肪酸或其衍生物。