1-(naphthalen-1-ylamino)-3-phenoxypropan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(naphthalen-1-ylamino)-3-phenoxypropan-2-ol
• 化学式: C₁₉H₁₉NO₂
• 分子量: 293.365
• InChiKey: UAQUNZCISZTTDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯基缩水甘油醚 、 1-萘胺 以 乙醇 为溶剂， 反应 5.0h， 以72%的产率得到1-(naphthalen-1-ylamino)-3-phenoxypropan-2-ol
  参考文献：
  名称：

  Synthesis of N-aryl derivatives of vicinal aminoalcohols

  摘要：

  Synthesis was performed of substituted 2-propanols based on glycidyl phenyl and glycidyl allyl ethers, Also some acetic acid esters were prepared.

  DOI：

  10.1134/s1070428007080155

文献信息

• Synthesis of N-aryl derivatives of vicinal aminoalcohols
  作者：E. G. Mesropyan、A. A. Avetisyan、A. S. Galstyan

  DOI：10.1134/s1070428007080155

  日期：2007.8

  Synthesis was performed of substituted 2-propanols based on glycidyl phenyl and glycidyl allyl ethers, Also some acetic acid esters were prepared.
• Mg(ClO₄)₂, an Efficient Catalyst for Synthesis of β-Amino Alcohols by Ring Opening of Epoxides with Amines under Solvent-Free Conditions
  作者：Abbas Ali Jafari、Moradgholi

  DOI：10.1080/00397911003629473

  日期：2011.1.31

  [image omitted] Commercially available magnesium perchlorate is reported as an extremely efficient catalyst for the ring-opening reaction of epoxide with various primary and secondary amines, especially diphenyl amine, under solvent-free conditions at room temperature.