A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated with cholestasis, particularly, primary biliary cirrhosis and primary sclerosing cholangitis, and a pharmaceutical useful as a therapeutic agent and a preventive agent for obesity, fatty liver and steatohepatitis are provided. A benzothiazepine or benzothiepine compound represented by the following formula (1A) having a thioamide bond and a quaternary ammonium substitutent:
提供了一种药物,可用作治疗和预防高脂血症的治疗剂和预防剂,以及一种药物,可用作治疗和预防与胆汁淤积有关的肝脏疾病,特别是原发性胆汁性肝硬化和原发性硬化性胆管炎的治疗剂和预防剂,以及一种药物,可用作治疗和预防肥胖症、
脂肪肝和
脂肪性肝炎的治疗剂和预防剂。化合物的
苯并噻吩或
苯并噻环代表如下式(1A),具有
硫酰胺键和季
铵取代基: