(+/-)-N-((R)-((1R,2S)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methylcyclopropyl)(phenyl)methyl)-P,P-diphenylphosphinamide

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (+/-)-N-((R)-((1R,2S)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methylcyclopropyl)(phenyl)methyl)-P,P-diphenylphosphinamide
• 英文别名: (1R)-1-[(1R,2S)-2-[2-[tert-butyl(diphenyl)silyl]oxyethyl]-1-methylcyclopropyl]-N-diphenylphosphoryl-1-phenylmethanamine
• 化学式: C₄₁H₄₆NO₂PSi
• 分子量: 643.881
• InChiKey: SXADWRBTYKWPET-RWBYEFGYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.24
• 重原子数：
  46
• 可旋转键数：
  13
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (+/-)-N-((R)-((1R,2S)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methylcyclopropyl)(phenyl)methyl)-P,P-diphenylphosphinamide 在 四丁基氟化铵 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 以96%的产率得到(+/-)-N-((R)-((1R,2S)-2-(2-hydroxyethyl)-1-methylcyclopropyl)(phenyl)methyl)-P,P-diphenylphosphinamide
  参考文献：
  名称：

  Three-Component Synthesis of α,β-Cyclopropyl-γ-Amino Acids

  摘要：

  [GRAPHICS]The multicomponent coupling of alkenylzirconocenes with N-diphenylphosphinoyl imines provides rapid access to functionalized C-cyclopropylalkylamides which have been readily transformed into alpha,beta-cyclopropyl-gamma-amino acids. These novel scaffolds are thus accessible in ca. 8 steps from commercially available alkynes.

  DOI：

  10.1021/ol0501525
• 作为产物：
  描述：

  二碘甲烷 、 N-亚苄基-P,P-二苯基次膦酸酰胺 、 tert-butyl((pent-3-ynyl)oxy)diphenylsilane 在 Schwartz's reagent Dimethylzinc 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 14.0h， 以61%的产率得到(+/-)-N-((R)-((1R,2S)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methylcyclopropyl)(phenyl)methyl)-P,P-diphenylphosphinamide
  参考文献：
  名称：

  Three-Component Synthesis of α,β-Cyclopropyl-γ-Amino Acids

  摘要：

  [GRAPHICS]The multicomponent coupling of alkenylzirconocenes with N-diphenylphosphinoyl imines provides rapid access to functionalized C-cyclopropylalkylamides which have been readily transformed into alpha,beta-cyclopropyl-gamma-amino acids. These novel scaffolds are thus accessible in ca. 8 steps from commercially available alkynes.

  DOI：

  10.1021/ol0501525

文献信息

• Three-Component Synthesis of α,β-Cyclopropyl-γ-Amino Acids
  作者：Peter Wipf、Corey R. J. Stephenson

  DOI：10.1021/ol0501525

  日期：2005.3.1

  [GRAPHICS]The multicomponent coupling of alkenylzirconocenes with N-diphenylphosphinoyl imines provides rapid access to functionalized C-cyclopropylalkylamides which have been readily transformed into alpha,beta-cyclopropyl-gamma-amino acids. These novel scaffolds are thus accessible in ca. 8 steps from commercially available alkynes.