3-isopropenyl-2-methyl-4-naphthalen-2-yl-6-piperidin-1-yl-benzonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-isopropenyl-2-methyl-4-naphthalen-2-yl-6-piperidin-1-yl-benzonitrile
• 英文别名: 2-Methyl-4-naphthalen-2-yl-6-piperidin-1-yl-3-prop-1-en-2-ylbenzonitrile；2-methyl-4-naphthalen-2-yl-6-piperidin-1-yl-3-prop-1-en-2-ylbenzonitrile
• 化学式: C₂₆H₂₆N₂
• 分子量: 366.506
• InChiKey: MIYOYUCMVXKOBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-甲基-3戊烯-2-酮 、 6-(2-naphthyl)-2-oxo-4-(1-piperidinyl)-2H-pyran-3-carbonitrile 在 氢氧化钾 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以72%的产率得到3-isopropenyl-2-methyl-4-naphthalen-2-yl-6-piperidin-1-yl-benzonitrile
  参考文献：
  名称：

  Regioselective synthesis of functionally hindered α-methylstyrenes through ring transformation of 2H-pyran-2-ones with mesityl oxide

  摘要：

  A regioselective synthesis of alpha-methylstyrenes with electron-withdrawing or -donating substituents is described and illustrated by carbanion-induced ring transformation of 2H-pyran-2-one with mesityl oxide in excellent yield. The potential of the reaction lies in the creation of an aromatic ring possessing an isopropenyl unit from six-membered lactones at room temperature under mild reaction conditions. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.09.084

文献信息

• Regioselective synthesis of functionally hindered α-methylstyrenes through ring transformation of 2H-pyran-2-ones with mesityl oxide
  作者：Amit Kumar、Fateh V. Singh、Atul Goel

  DOI：10.1016/j.tetlet.2007.09.084

  日期：2007.11

  A regioselective synthesis of alpha-methylstyrenes with electron-withdrawing or -donating substituents is described and illustrated by carbanion-induced ring transformation of 2H-pyran-2-one with mesityl oxide in excellent yield. The potential of the reaction lies in the creation of an aromatic ring possessing an isopropenyl unit from six-membered lactones at room temperature under mild reaction conditions. (C) 2007 Elsevier Ltd. All rights reserved.