1-chloro-3-oxo-1,3-dihydroisobenzofuran-1-carboxylic acid benzyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 1-chloro-3-oxo-1,3-dihydroisobenzofuran-1-carboxylic acid benzyl ester
• 英文别名: benzyl 1-chloro-3-oxo-1,3-dihydro-isobenzofuran-1-carboxylate；Benzyl 1-chloro-3-oxo-2-benzofuran-1-carboxylate
• 化学式: C₁₆H₁₁ClO₄
• 分子量: 302.714
• InChiKey: WFUFAHKENPPIFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-chloro-3-oxo-1,3-dihydroisobenzofuran-1-carboxylic acid benzyl ester 、 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile 在 Bu₃SnH 作用下， 以 苯 为溶剂， 以23%的产率得到benzyl 3-oxo-1,3-dihydroisobenzofuran-1-carboxylate
  参考文献：
  名称：

  Selective preventives/remedies for progressive lesions after organ damage

  摘要：

  本发明的目的是提供一种药物制剂，用于在有机损伤后预防和/或治疗渐进性病变，而不抑制有机功能或再生功能，通过选择性抑制细胞毒性效应巨噬细胞的诱导，这些巨噬细胞是在损伤的器官中受化学因子和细胞因子诱导而表达的，这些化学因子和细胞因子取决于损伤的有机组织的类型。

  公开号：

  US20030181506A1

文献信息

• SELECTIVE PREVENTIVES/REMEDIES FOR PROGRESSIVE LESIONS AFTER ORGAN DAMAGE
  申请人：Ishibashi, Michio

  公开号：EP1277747A1

  公开（公告）日：2003-01-22

  An object of the present invention is to provide a pharmaceutical agents for preventing and/or treating the progressive lesion after the organic damage without inhibiting organic function or regeneration function thereof, by selectively suppressing the induction of cytotoxic effector macrophages which are induced into the damaged organs in response to chemokines and cytokines which are expressed depending on the type of damaged organic tissues.

  本发明的目的是提供一种药剂，通过选择性地抑制细胞毒性效应巨噬细胞的诱导，预防和/或治疗机体损伤后的进行性病变，而不抑制机体功能或其再生功能。
• DRUG OR COSMETIC
  申请人：Ishibashi, Michio

  公开号：EP1541174A1

  公开（公告）日：2005-06-15

  The present invention provides pharmaceuticals or cosmetics, which prevent sclerotic lesions causing apoptosis, degeneration, fibrosis and atrophy, and repair and regenerate the lesions selectively, comprising a compound which preferentially increases regeneration-promoting macrophages and a method for screening the compound which preferentially increases regeneration-promoting macrophages. Pharmaceuticals or cosmetics of the present invention are useful for renal lesions, pancreatic lesions and skin lesions, because these induce regeneration-promoting immunocompetent cells lesion-selectively against organ tissue disorders and cause repair and regeneration thereof. The present invention provides pharmaceuticals or cosmetics, which prevent sclerotic lesions causing apoptosis, degeneration, fibrosis and atrophy, and repair and regenerate the lesions selectively, comprising a compound which preferentially increases regeneration-promoting macrophages and a method for screening the compound which preferentially increases regeneration-promoting macrophages. Pharmaceuticals or cosmetics of the present invention are useful for renal lesions, pancreatic lesions and skin lesions, because these induce regeneration-promoting immunocompetent cells lesion-selectively against organ tissue disorders and cause repair and regeneration thereof.

  本发明提供了防止硬化性病变引起细胞凋亡、变性、纤维化和萎缩，并有选择地修复和再生病变的药物或化妆品，包括优先增加促进再生的巨噬细胞的化合物和筛选优先增加促进再生的巨噬细胞的化合物的方法。本发明的药物或化妆品可用于肾脏病变、胰腺病变和皮肤病变，因为这些药物或化妆品可针对器官组织病变有选择地诱导促进再生的免疫功能细胞，并使其修复和再生。 本发明提供了防止硬化性病变导致细胞凋亡、变性、纤维化和萎缩，并有选择性地修复和再生病变的药物或化妆品，其中包括优先增加促进再生的巨噬细胞的化合物和筛选优先增加促进再生的巨噬细胞的化合物的方法。本发明的药物或化妆品可用于肾脏病变、胰腺病变和皮肤病变，因为这些药物或化妆品可针对器官组织病变有选择地诱导促进再生的免疫机能细胞，并使其修复和再生。
• Method for screening for a substance for promoting regeneration of macrophages
  申请人：Ishibashi, Michio

  公开号：EP1950563A2

  公开（公告）日：2008-07-30

  The present invention provides a method for screening a compound that lesion-selectively induces regeneration-promoting immunocompetent cells inducing the immunoregulatory response of the repair and regeneration selectively on the lesion part.

  本发明提供了一种筛选化合物的方法，该化合物可在病变部位选择性地诱导促进再生的免疫功能细胞，诱导病变部位选择性地产生修复和再生的免疫调节反应。
• Selective preventing and therapeutic agents for progressive lesion after organic damage
  申请人：Ishibashi Michio

  公开号：US20050143453A1

  公开（公告）日：2005-06-30

  An object of the present invention is to provide a pharmaceutical agents for preventing and/or treating the progressive lesion after the organic damage without inhibiting organic function or regeneration function thereof, by selectively suppressing the induction of cytotoxic effector macrophages which are induced into the damaged organs in response to chemokines and cytokines which are expressed depending on the type of damaged organic tissues.

  本发明的目的是提供一种药剂，通过选择性地抑制细胞毒性效应巨噬细胞的诱导，预防和/或治疗机体损伤后的进行性病变，而不抑制机体功能或其再生功能。
• Drug or cosmetic
  申请人：Ishibashi Michio

  公开号：US20060014709A1

  公开（公告）日：2006-01-19

  The present invention provides pharmaceuticals or cosmetics, which prevent sclerotic lesions causing apoptosis, degeneration, fibrosis and atrophy, and repair and regenerate the lesions selectively, comprising a compound which preferentially increases regeneration-promoting macrophages and a method for screening the compound which preferentially increases regeneration-promoting macrophages. Pharmaceuticals or cosmetics of the present invention are useful for renal lesions, pancreatic lesions and skin lesions, because these induce regeneration-promoting immunocompetent cells lesion-selectively against organ tissue disorders and cause repair and regeneration thereof.

  本发明提供了防止硬化性病变引起细胞凋亡、变性、纤维化和萎缩，并有选择地修复和再生病变的药物或化妆品，包括优先增加促进再生的巨噬细胞的化合物和筛选优先增加促进再生的巨噬细胞的化合物的方法。本发明的药物或化妆品可用于肾脏病变、胰腺病变和皮肤病变，因为这些药物或化妆品可针对器官组织病变有选择地诱导促进再生的免疫细胞，并使其修复和再生。