gentixathone A₂

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: gentixathone A₂
• 英文别名: 1,3,5,8-tetrahydroxyxanthone1-O-β-D-glucopyranosyl(1→6)-β-D-glucopyranoside
• 化学式: C₂₅H₂₈O₁₆
• 分子量: 584.488
• InChiKey: HNJAWUURPUIMKX-NGQOZTOASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.93
• 重原子数：
  41.0
• 可旋转键数：
  6.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  269.43
• 氢给体数：
  10.0
• 氢受体数：
  16.0

反应信息

• 作为反应物：
  描述：

  gentixathone A₂ 在 盐酸 、 水 作用下， 反应 3.0h， 生成 可得然胶
  参考文献：
  名称：

  Bioactive gentixanthone and gentichromone from the whole plants of Gentianella acuta (Michx.) Hulten

  摘要：

  Five new compounds, gentixanthones A(1) (1), A(2) (2), and gentichromones A(1)-A(3) (3-5), together with thirteen known xanthones (6-18) were obtained from the whole plants of Gentianella acuta (Michx.) Hulten. Their structures were elucidated by chemical and spectroscopic methods. Among them, compounds 6, 8, 13, 14, and 17 were obtained from Gentianella genus firstly, and 7, 12, 15, 16, and 18 were isolated from this plant for the first time. Meanwhile, inhibitory effects of 1-18 on motility of mouse isolated intestine tissue were determined. As results, xanthones 1, 2, 6, 7, 9,10 and 14 were found to have significant reduce effect on intestine contraction tension, and structure-activity relationship was discussed. (C) 2016 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.fitote.2016.08.001

文献信息

• Bioactive gentixanthone and gentichromone from the whole plants of Gentianella acuta (Michx.) Hulten
  作者：Yanxia Liu、Yajuan Ni、Jingya Ruan、Lu Qu、Haiyang Yu、Lifeng Han、Yi Zhang、Tao Wang

  DOI：10.1016/j.fitote.2016.08.001

  日期：2016.9

  Five new compounds, gentixanthones A(1) (1), A(2) (2), and gentichromones A(1)-A(3) (3-5), together with thirteen known xanthones (6-18) were obtained from the whole plants of Gentianella acuta (Michx.) Hulten. Their structures were elucidated by chemical and spectroscopic methods. Among them, compounds 6, 8, 13, 14, and 17 were obtained from Gentianella genus firstly, and 7, 12, 15, 16, and 18 were isolated from this plant for the first time. Meanwhile, inhibitory effects of 1-18 on motility of mouse isolated intestine tissue were determined. As results, xanthones 1, 2, 6, 7, 9,10 and 14 were found to have significant reduce effect on intestine contraction tension, and structure-activity relationship was discussed. (C) 2016 Elsevier B.V. All rights reserved.