2-(2-phenoxy)ethylquinazolin-4(3H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(2-phenoxy)ethylquinazolin-4(3H)-one
• 英文别名: 2-(2-phenoxyethyl)-3H-quinazolin-4-one
• 化学式: C₁₆H₁₄N₂O₂
• 分子量: 266.299
• InChiKey: MHEYFZKQXUUJDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-苯氧基丙腈 、 邻氨基苯甲酸甲酯 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 6.0h， 以64%的产率得到2-(2-phenoxy)ethylquinazolin-4(3H)-one
  参考文献：
  名称：

  Shishoo; Shirsath; Rathod, Arzneimittel-Forschung/Drug Research, 2001, vol. 51, # 3, p. 221 - 231

  摘要：

  DOI：

文献信息

• PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1345925A2

  公开（公告）日：2003-09-24
• [EN] PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS<br/>[FR] COMPOSES DE PYRAZOLE PRESENTANT UNE GRANDE UTILITE COMME INHIBITEURS DE PROTEINE KINASE
  申请人：VERTEX PHARMA

  公开号：WO2002050065A2

  公开（公告）日：2002-06-27

  This invention describes novel pyrazole compound of formula (IIc): wherein R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R?x and Ry¿ are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-7 membered ring having 0-3 heteroatoms; and R?2 and R2'¿ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
• Shishoo; Shirsath; Rathod, Arzneimittel-Forschung/Drug Research, 2001, vol. 51, # 3, p. 221 - 231
  作者：Shishoo、Shirsath、Rathod、Patil、Bhargava

  DOI：——

  日期：——