O-[5'-O-tritylthymidin-3'-yl] O-[N⁶-benzoyl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxyadenosin-5'-yl] O-(2-cyanoethyl)phosphite

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: O-[5'-O-tritylthymidin-3'-yl] O-[N⁶-benzoyl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxyadenosin-5'-yl] O-(2-cyanoethyl)phosphite
• 英文别名: [(2R,3S,5R)-5-(6-benzamidopurin-9-yl)-3-[tert-butyl(diphenyl)silyl]oxyoxolan-2-yl]methyl 2-cyanoethyl [(2R,3S,5R)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)-2-(trityloxymethyl)oxolan-3-yl] phosphite
• 化学式: C₆₅H₆₅N₈O₁₀PSi
• 分子量: 1177.34
• InChiKey: ZWEJFMGWJFADBY-SJTGVAERSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.03
• 重原子数：
  85
• 可旋转键数：
  23
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  211
• 氢给体数：
  2
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  N⁶-benzoyl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxyadenosine 在 三甲基氯硅烷 作用下， 以 四氢呋喃 为溶剂， 反应 20.08h， 生成 O-[5'-O-tritylthymidin-3'-yl] O-[N⁶-benzoyl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxyadenosin-5'-yl] O-(2-cyanoethyl)phosphite
  参考文献：
  名称：

  The phosphorofluoroamidite approach to mixed phosphites

  摘要：

  A new convenient and general procedure is described for the preparation of mixed phosphites from readily available phosphorofluoroamidites by stepwise replacement of amino and fluoro-groups in the presence of trimethylchlorosilane (Me3SiCl). The reaction mechanism is briefly discussed. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-328x(01)01379-1

文献信息

• The phosphorofluoroamidite approach to mixed phosphites
  作者：Izabela Tworowska、Wojciech Dąbkowski、Łucja Kaźmierczak、Jan Michalski

  DOI：10.1016/s0022-328x(01)01379-1

  日期：2002.2

  A new convenient and general procedure is described for the preparation of mixed phosphites from readily available phosphorofluoroamidites by stepwise replacement of amino and fluoro-groups in the presence of trimethylchlorosilane (Me3SiCl). The reaction mechanism is briefly discussed. (C) 2002 Elsevier Science B.V. All rights reserved.