十八烷基硫酸酯铵 | 4696-46-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 中文名称: 十八烷基硫酸酯铵
• 英文名称: octadecyl sulfate ammonium salt
• 英文别名: octadecyl sulfate ammonium；Sulfuric acid, monooctadecyl ester, ammonium salt；azane;octadecyl hydrogen sulfate
• CAS: 4696-46-2
• 化学式: C₁₈H₃₈O₄S*H₃N
• 分子量: 367.594
• InChiKey: NGOVNSCURCOLBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.23
• 重原子数：
  24.0
• 可旋转键数：
  18.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  98.6
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  溴化N-辛基-3-甲基吡啶 、 十八烷基硫酸酯铵 以 水 为溶剂， 反应 0.17h， 以96%的产率得到1-octyl-3-methylpyridinium octadecyl sulfate
  参考文献：
  名称：

  Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility

  摘要：

  定制的离子液体溶解了水溶性较差的药物丹诺酮和伊曲康唑的大量，而丹诺酮自乳化离子液体配方的曝光量比晶体药物和脂质配方分别更高且更持久。

  DOI：

  10.1039/c3cc48650h
• 作为产物：
  描述：

  硬脂醇 在 氨基磺酸 作用下， 反应 24.0h， 以80%的产率得到十八烷基硫酸酯铵
  参考文献：
  名称：

  Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility

  摘要：

  定制的离子液体溶解了水溶性较差的药物丹诺酮和伊曲康唑的大量，而丹诺酮自乳化离子液体配方的曝光量比晶体药物和脂质配方分别更高且更持久。

  DOI：

  10.1039/c3cc48650h

文献信息

• [EN] COMPOSITIONS AND PREPARATION METHODS OF LOW MELTING IONIC SALTS OF POORLY- WATER SOLUBLE DRUGS<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE PRÉPARATION DE SELS IONIQUES À BAS POINT DE FUSION DE MÉDICAMENTS FAIBLEMENT HYDROSOLUBLES
  申请人：UNIV MONASH

  公开号：WO2015013772A1

  公开（公告）日：2015-02-05

  The disclosure relates generally to ionic salts, particularly low-melting ionic salts such as ionic liquids, of poorly- water soluble drugs. The disclosure further relates to methods of preparing the ionic salts of poorly-water soluble drugs, lipid formulations comprising them and their use in drug delivery.

  该披露通常涉及离子盐，特别是低熔点离子盐，例如贫水溶性药物的离子液体。该披露进一步涉及制备贫水溶性药物的离子盐的方法，包含它们的脂质配方以及它们在药物递送中的使用。
• COMPOSITIONS AND PREPARATION METHODS OF LOW MELTING IONIC SALTS OF POORLY-WATER SOLUBLE DRUGS
  申请人：MW ENCAP LIMITED

  公开号：US20160151503A1

  公开（公告）日：2016-06-02

  The disclosure relates generally to ionic salts, particularly low-melting ionic salts such as ionic liquids, of poorly-water soluble drugs. The disclosure further relates to methods of preparing the ionic salts of poorly-water soluble drugs, lipid formulations comprising them and their use in drug delivery.

  本发明涉及离子盐，特别是低熔点的离子盐，例如离子液体，用于难溶于水的药物。本发明还涉及制备难溶于水的药物的离子盐的方法，包含它们的脂质配方以及它们在药物输送中的使用。
• Resin compositions having improved antistatic properties
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0422879A1

  公开（公告）日：1991-04-17

  Disclosed is a resin composition having excellent antistatic properties and practical physical properties. The resin comprises (i) a styrene resin; (ii) a polyethylene oxide having a viscosity-average molecular weight ranging from 15,000 to 1,200,000; (iii) either or both of a (meth) acrylate resin and an oxide selected from the group consisting of titanium oxide, zinc oxide and magnesium oxide; (iv) either a surfactant selected from specific sulfonic acid salts or a surfactant selected from specific alkyl sulfates; and, optionally, (v) a (poly)ethylene glycol having an average molecular weight ranging from 62 to 1,200. The resin composition also provides excellent resistance to hot water.

  本发明公开了一种具有优异抗静电性能和实用物理性能的树脂组合物。该树脂包括：(i) 苯乙烯树脂；(ii) 聚氧化乙烯，其粘度-平均分子量在 15,000 至 1,200,000 之间；(iii) (甲基) 丙烯酸酯树脂和选自氧化钛、氧化锌和氧化镁的氧化物中的一种或两种；(iv) 选自特定磺酸盐的表面活性剂或选自特定烷基硫酸盐的表面活性剂；以及 (v) 平均分子量在 62 到 1 200 之间的（聚）乙二醇。这种树脂组合物还具有优异的耐热水性。
• CROSS-LINKED SPHERICAL PARTICULATE, PRODUCTION THEREOF, COATING COMPOSITION AND RELEASABLE PRESSURE-SENSITIVE ADHESIVE PRODUCED FROM SAID PARTICULATE, AND ARTICLE COMPRISING THE SAME AS LAMINAR COMPONENT
  申请人：NIPPON SHOKUBAI CO., LTD.

  公开号：EP0420988A1

  公开（公告）日：1991-04-10

  This invention discloses a cross-linked spherical particulate having good toughness and elasticity and excellent chemical properties and a method of producing said particulate by polymerizing a dispersion of a radical-polymerizable component (M) containing a radical-polymerizable vinylic compound (V) prepared by the reaction of a specified polyol (a), an isocyanate compound (b), and a radical-polymerizable vinyl monomer (c) having an active hydrogen group. Also disclosed are a coating composition produced from said particulate, a filmy or sheetlike article and an adhesive filmy or sheetlike article produced from said composition, and a releasable pressure-sensitive adhesive and an article thereof produced from said particulate.

  本发明公开了一种交联球形微粒，该微粒具有良好的韧性和弹性以及优异的化学性质，并公开了一种生产该微粒的方法，该方法是通过聚合可自由基聚合组分（M）的分散体，该分散体含有可自由基聚合的乙烯基化合物（V），该乙烯基化合物是由特定的多元醇（a）、异氰酸酯化合物（b）和具有活性氢基的可自由基聚合乙烯基单体（c）反应制备的。还公开了由所述微粒制得的涂层组合物、由所述组合物制得的薄膜状或片状制品和粘合剂薄膜状或片状制品，以及由所述微粒制得的可释放压敏粘合剂及其制品。
• POLYOLEFIN RESIN COMPOSITE, THERMOPLASTIC RESIN COMPOSITE, AND PROCESS FOR PRODUCING THERMOPLASTIC RESIN COMPOSITE
  申请人：SEKISUI CHEMICAL CO., LTD.

  公开号：EP1193290A1

  公开（公告）日：2002-04-03

  A polyolefinic resin composite material is provided as a nanocomposite excellent in mechanical strength, thermal properties and gas barrier properties. A polyolefinic resin composite material containing 100 parts by weight of a polyolefinic resin and 0.1 - 50 parts by weight of an organically-modified layered silicate, wherein the organically-modified layered silicate is derived via ion-exchange of metal ions originally present as exchangeable cations in a crystal structure of a layered silicate with a cationic surfactant, and wherein a hydroxyl group present on a crystal face of the organically-modified layered silicate is chemically modified by a chemical substance containing at its molecular end a functional group having a tendency to chemically couple to the hydroxyl group or a chemical affinity for the hydroxyl group.

  提供一种聚烯烃树脂复合材料，作为一种纳米复合材料，其机械强度、热性能和气体阻隔性能都非常出色。 一种聚烯烃树脂复合材料含有 100 重量份的聚烯烃树脂和 0.有机改性层状硅酸盐，其中有机改性层状硅酸盐是通过层状硅酸盐晶体结构中原本作为可交换阳离子存在的金属离子与阳离子表面活性剂进行离子交换而得到的，有机改性层状硅酸盐晶面上存在的羟基被一种化学物质进行化学改性，该化学物质的分子端含有一种官能团，该官能团具有与羟基化学偶联的倾向或与羟基具有化学亲和性。