1-(4-isopropoxyphenyl)-2-(3,4-dimethoxyphenyl)ethanone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-(4-isopropoxyphenyl)-2-(3,4-dimethoxyphenyl)ethanone
• 英文别名: 2-(3,4-Dimethoxyphenyl)-1-(4-propan-2-yloxyphenyl)ethanone
• 化学式: C₁₉H₂₂O₄
• 分子量: 314.381
• InChiKey: VOZLHCIHZVJNKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,4-dimethoxybenzenediazonium tetrafluoroborate 、 4-isopropoxystyrene 在 维生素 C 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 以48%的产率得到1-(4-isopropoxyphenyl)-2-(3,4-dimethoxyphenyl)ethanone
  参考文献：
  名称：

  Ascorbic Acid Promoted Oxidative Arylation of Vinyl Arenes to 2-Aryl Acetophenones without Irradiation at Room Temperature under Aerobic Conditions

  摘要：

  A convenient and general protocol for oxidative arylation of vinyl arenes by aryl radicals generated in situ from arene diazonium fluoroborates promoted by ascorbic acid in air at room temperature has been developed in the absence of any additive and visible light irradiation. A series of diversely substituted 2-aryl acetophenones have been obtained in good yields by this procedure.

  DOI：

  10.1021/acs.joc.5b00825

文献信息

• Unterhalt; Fahrig, Scientia Pharmaceutica, 1996, vol. 64, # 3-4, p. 679 - 686
  作者：Unterhalt、Fahrig

  DOI：——

  日期：——
• Ascorbic Acid Promoted Oxidative Arylation of Vinyl Arenes to 2-Aryl Acetophenones without Irradiation at Room Temperature under Aerobic Conditions
  作者：Biju Majhi、Debasish Kundu、Brindaban C. Ranu

  DOI：10.1021/acs.joc.5b00825

  日期：2015.8.7

  A convenient and general protocol for oxidative arylation of vinyl arenes by aryl radicals generated in situ from arene diazonium fluoroborates promoted by ascorbic acid in air at room temperature has been developed in the absence of any additive and visible light irradiation. A series of diversely substituted 2-aryl acetophenones have been obtained in good yields by this procedure.