1-benzoyl-8,9-dimethoxy-1,5,6,10b-tetrahydro-2H-imidazo[2,1-a]isoquinolin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 1-benzoyl-8,9-dimethoxy-1,5,6,10b-tetrahydro-2H-imidazo[2,1-a]isoquinolin-3-one
• 英文别名: 1-Benzoyl-8,9-dimethoxy-2,5,6,10b-tetrahydroimidazo[2,1-a]isoquinolin-3-one；1-benzoyl-8,9-dimethoxy-2,5,6,10b-tetrahydroimidazo[2,1-a]isoquinolin-3-one
• 化学式: C₂₀H₂₀N₂O₄
• 分子量: 352.39
• InChiKey: SEMMXANSXCBFCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-苯基-5-噁唑酮 、 6,7-二甲氧基-3,4-二氢异喹啉 以 乙腈 为溶剂， 反应 1.0h， 以18%的产率得到1-benzoyl-8,9-dimethoxy-1,5,6,10b-tetrahydro-2H-imidazo[2,1-a]isoquinolin-3-one
  参考文献：
  名称：

  Three Distinct Reactions of 3,4-Dihydroisoquinolines with Azlactones:  Novel Synthesis of Imidazoloisoquinolin-3-ones, Benzo[a]quinolizin-4-ones, and Benzo[d]azocin-4-ones

  摘要：

  [GRAPHICS]A facile and direct synthetic entry to tricyclic imidazoloisoquinolin-3-ones and benzo[a] quinolizin-4-ones is reported based on the ring annulation of 1-unsubstituted and 1-substituted dihydroisoquinolines with azlactones under neutral conditions in a one-step procedure. Bicyclic 2,3dihydrobenzo[d]azocin-4-ones were also prepared using simple azlactone and 1-substituted dihydroisoquinolines in a one-pot reaction.

  DOI：

  10.1021/ol062429m

文献信息

• Three Distinct Reactions of 3,4-Dihydroisoquinolines with Azlactones:  Novel Synthesis of Imidazoloisoquinolin-3-ones, Benzo[<i>a</i>]quinolizin-4-ones, and Benzo[<i>d</i>]azocin-4-ones
  作者：Rattana Worayuthakarn、Nopporn Thasana、Somsak Ruchirawat

  DOI：10.1021/ol062429m

  日期：2006.12.1

  [GRAPHICS]A facile and direct synthetic entry to tricyclic imidazoloisoquinolin-3-ones and benzo[a] quinolizin-4-ones is reported based on the ring annulation of 1-unsubstituted and 1-substituted dihydroisoquinolines with azlactones under neutral conditions in a one-step procedure. Bicyclic 2,3dihydrobenzo[d]azocin-4-ones were also prepared using simple azlactone and 1-substituted dihydroisoquinolines in a one-pot reaction.