卡拉亭 | 20304-47-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 卡拉亭
• 英文名称: calactin
• 英文别名: (1S,3R,5S,7R,9R,10S,12R,14R,15S,18R,19R,22S,23R)-9,10,22-trihydroxy-7,18-dimethyl-19-(5-oxo-2H-furan-3-yl)-4,6,11-trioxahexacyclo[12.11.0.03,12.05,10.015,23.018,22]pentacosane-14-carbaldehyde
• CAS: 20304-47-6
• 化学式: C₂₉H₄₀O₉
• 分子量: 532.631
• InChiKey: OWPWFVVPBYFKBG-SXDHXEJRSA-N

物化性质

• 熔点：
  275-277 °C
• 沸点：
  733.5±60.0 °C(Predicted)
• 密度：
  1.403±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  38
• 可旋转键数：
  2
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  132
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• THERAPEUTIC TREATMENT OF MICROSATELLITE UNSTABLE CANCERS
  申请人：THE BROAD INSTITUTE, INC.

  公开号：US20220133693A1

  公开（公告）日：2022-05-05

  The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of microsatellite unstable cancers. In particular, the instant disclosure provides for identification of a cancer as exhibiting microsatellite instability (MSI) and/or impaired mismatch repair (MMR), and selection and/or administration of an inhibitor of the WRN helicase as a therapeutic agent for such a cancer and/or subject having or at risk of developing such a cancer.