7-tert-Butyl-1-methoxynaphthalene

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-tert-Butyl-1-methoxynaphthalene
• 化学式: C₁₅H₁₈O
• 分子量: 214.307
• InChiKey: BXPXYQXPVICJQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-甲氧基萘 、 叔丁醇 在 硫酸 作用下， 以 溶剂黄146 为溶剂， 反应 0.17h， 以12%的产率得到3,7-Di-tert-butyl-1-methoxynaphthalene
  参考文献：
  名称：

  Regioselectivity in the Friedel-Crafts tert-Butylation of 1-Naphthol

  摘要：

  DOI：

  10.1021/jo00114a049

文献信息

• Vinblastine 20″ amides: synthetic analogs that maintain or improve potency and simultaneously overcome Pgp-derived efflux and resistance
  申请人：The Scripps Research Institute

  公开号：US10689381B2

  公开（公告）日：2020-06-23

  A vinca alkaloid compound substituted at the 20′-position with a carboxamido group is disclosed. The carbonyl of the carboxamido group is bonded to a 20′-amino group and to a ring system that contains up to three 5-, 6- or 7-membered rings that are fused or otherwise bonded together. Each ring can be carbocyclic or heterocyclic, with a heterocyclic ring containing up to three hetero ring atoms that are the same or different and are selected from nitrogen, oxygen and sulfur. The ring system can include up to four substituent groups other than hydrogen that are discussed within. Methods of preparing the compounds are disclosed as are compositions for their use and methods of treatment using d compound. A particularly preferred compound has an activity in specified cancer cell growth inhibition assays that is the same or better than its parental, unsubstituted vinca compound and is not subject to Pgp-mediated efflux.

  本发明公开了一种在 20′位被羧酰胺基取代的长春花生物碱化合物。羧酰胺基团的羰基与 20′-氨基基团和一个环系统键合，该环系统包含最多三个融合或以其他方式键合在一起的 5、6 或 7 元环。每个环可以是碳环或杂环，其中杂环含有最多三个相同或不同的杂环原子，这些原子选自氮、氧和硫。除氢外，该环系还可包括多达四个取代基团。公开了制备化合物的方法以及使用这些化合物的组合物和使用 d 化合物进行治疗的方法。一种特别优选的化合物在特定癌细胞生长抑制实验中的活性与其亲本未取代的长春花化合物相同或更好，并且不受 Pgp 介导的外流影响。
• VINBLASTINE 20' AMIDES: SYNTHETIC ANALOGS THAT MAINTAIN OR IMPROVE POTENCY AND SIMULTANEOUSLY OVERCOME Pgp-DERIVED EFFLUX AND RESISTANCE
  申请人：The Scripps Research Institute

  公开号：US20190119277A1

  公开（公告）日：2019-04-25

  A vinca alkaloid compound substituted at the 20′-position with a carboxamido group is disclosed. The carbonyl of the carboxamido group is bonded to a 20′-amino group and to a ring system that contains up to three 5-, 6- or 7-membered rings that are fused or otherwise bonded together. Each ring can be carbocyclic or heterocyclic, with a heterocyclic ring containing up to three hetero ring atoms that are the same or different and are selected from nitrogen, oxygen and sulfur. The ring system can include up to four substituent groups other than hydrogen that are discussed within. Methods of preparing the compounds are disclosed as are compositions for their use and methods of treatment using d compound. A particularly preferred compound has an activity in specified cancer cell growth inhibition assays that is the same or better than its parental, unsubstituted vinca compound and is not subject to Pgp-mediated efflux.
• [EN] 1,2-NAPHTHOQUINONE DERIVATIVE AND METHOD FOR PREPARING SAME<br/>[FR] DÉRIVÉ DE 1,2-NAPHTHOQUINONE ET SON PROCÉDÉ DE PRÉPARATION<br/>[KO] 1,2 나프토퀴논 유도체 및 이의 제조방법
  申请人：KT&G LIFE SCIENCES CORP

  公开号：WO2016159576A2

  公开（公告）日：2016-10-06

  본 발명은 제1항에 정의된 화학식 (1)로 표시되는 화합물, 그것의 약제학적으로 허용되는 염, 수화물, 용매화물, 프로드럭, 토토머(tautomer), 거울상 이성질체 또는 약학적으로 허용 가능한 부분입체 이성질체를 제공한다.
• Regioselectivity in the Friedel-Crafts tert-Butylation of 1-Naphthol
  作者：Paris E. Georghiou、Muhammad Ashram

  DOI：10.1021/jo00114a049

  日期：1995.5