8,10-diamino-2,3-dihydro-11H-[1,4]dioxino[2',3':6,7]chromeno[2,3-b]pyridine-9-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 8,10-diamino-2,3-dihydro-11H-[1,4]dioxino[2',3':6,7]chromeno[2,3-b]pyridine-9-carbonitrile
• 英文别名: 5,7-Diamino-2,13,16-trioxa-4-azatetracyclo[8.8.0.03,8.012,17]octadeca-1(18),3,5,7,10,12(17)-hexaene-6-carbonitrile
• 化学式: C₁₅H₁₂N₄O₃
• 分子量: 296.285
• InChiKey: HEHZARWPCGQYLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1,1-二溴乙烷 、 2,4-diamino-7,8-dihydroxy-5H-chromeno[2,3-b]pyridine-3-carbonitrile 在 sodium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 以18%的产率得到8,10-diamino-2,3-dihydro-11H-[1,4]dioxino[2',3':6,7]chromeno[2,3-b]pyridine-9-carbonitrile
  参考文献：
  名称：

  Tricyclic aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase-2

  摘要：

  描述了能够抑制丝裂原活化蛋白激酶-2的氨基氰基吡啶化合物。还描述了包含氨基氰基吡啶MK-2抑制化合物的药物组合物和试剂盒。

  公开号：

  US20040127511A1

文献信息

• Method of making tricyclic aminocyanopyridine compounds
  申请人：Pharmacia Corporation

  公开号：US20040127714A1

  公开（公告）日：2004-07-01

  A method of making aminocyanopyridine compounds which are capable of inhibiting mitogen activated protein kinase-activated protein kinase-2 is described.

  本文描述了一种制备能够抑制有丝分裂原活化蛋白激酶-激活蛋白激酶-2的氨基氰吡啶化合物的方法。
• Method of using aminocyanopyridine compounds as mitogen activated protein kinase-activated protein kinase-2 inhibitors
  申请人：Pharmacia Corporation

  公开号：US20040127519A1

  公开（公告）日：2004-07-01

  A method is described for inhibiting mitogen activated protein kinase-activated protein kinase-2 in a subject in need of such inhibition, where the method involves administering to the subject an anminocyanopyridine MK-2 inhibiting compound, or a pharmaceutically acceptable salt thereof.

  本文描述了一种抑制需要抑制的受试者中的有丝分裂原活化蛋白激酶激活蛋白激酶-2的方法，其中该方法涉及向受试者给予一种抑制MK-2的氨基氰基吡啶化合物或其药学上可接受的盐。
• Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
  作者：David R. Anderson、Shridhar Hegde、Emily Reinhard、Leslie Gomez、William F. Vernier、Len Lee、Shuang Liu、Aruna Sambandam、Patricia A. Snider、Liaqat Masih

  DOI：10.1016/j.bmcl.2005.01.067

  日期：2005.3

  A class of inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) was discovered. These compounds have demonstrated activity against the enzyme with IC50 values as low as 130 nM and suppress the expression of TNFα in U937 cells. These represent the first small molecule inhibitors of MK-2 to be reported. © 2005 Elsevier Ltd. All rights reserved.
• METHOD OF USING AMINOCYANOPYRIDINE COMPOUNDS AS MITOGEN ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITORS
  申请人：Pharmacia Corporation

  公开号：EP1569645A2

  公开（公告）日：2005-09-07
• METHOD OF MAKING TRICYCLIC AMINOCYANOPYRIDINE COMPOUNDS
  申请人：Pharmacia Corporation

  公开号：EP1569938A1

  公开（公告）日：2005-09-07