(E)-2-[(4,5-dihydro-1H-imidazol-2-ylmethyl)amino]benzaldehyde O-methyloxime

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (E)-2-[(4,5-dihydro-1H-imidazol-2-ylmethyl)amino]benzaldehyde O-methyloxime
• 英文别名: N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-[(E)-methoxyiminomethyl]aniline
• 化学式: C₁₂H₁₆N₄O
• 分子量: 232.285
• InChiKey: PTJZNEIRBPOVRN-LZYBPNLTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (E)-2-nitrobenzaldehyde O-methyl oxime 在 sodium sulfide 作用下， 生成 (E)-2-[(4,5-dihydro-1H-imidazol-2-ylmethyl)amino]benzaldehyde O-methyloxime
  参考文献：
  名称：

  2-(Anilinomethyl)imidazolines as α1A Adrenergic Receptor Agonists: 2′-Heteroaryl and 2′-Oxime Ether Series

  摘要：

  A series of 2'-heteroaryl and 2'-oxime anilinomethylimidazolines was prepared and evaluated in in vitro functional assays for cloned human alpha(1A), alpha(1B), and alpha(1D) receptor subtypes, Potent and selective alpha(1A) agonists have been identified in these series. (C) 2002 Elsevier Science Lid. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00822-8

文献信息

• US6884801B1
  申请人：——

  公开号：US6884801B1

  公开（公告）日：2005-04-26
• 2-(Anilinomethyl)imidazolines as α1A Adrenergic Receptor Agonists: 2′-Heteroaryl and 2′-Oxime Ether Series
  作者：Frank Navas、Michael J. Bishop、Deanna T. Garrison、Stephen J. Hodson、Jason D. Speake、Eric C. Bigham、David H. Drewry、David L. Saussy、James H. Liacos、Paul E. Irving、M.Jeffrey Gobel

  DOI：10.1016/s0960-894x(01)00822-8

  日期：2002.2

  A series of 2'-heteroaryl and 2'-oxime anilinomethylimidazolines was prepared and evaluated in in vitro functional assays for cloned human alpha(1A), alpha(1B), and alpha(1D) receptor subtypes, Potent and selective alpha(1A) agonists have been identified in these series. (C) 2002 Elsevier Science Lid. All rights reserved.